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Abstract: We are grateful for the constructive comments given by Babic et al. (2013) on our article recently published in the Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) (Pu et al., 2012). The aim of this study was to generate a logistic regression model to predict the presence of significant atherosclerotic renal artery stenosis (ARAS) defined as luminal diameter stenosis ≥70% of uni- or bilateral renal arteries using clinical, biochemical, and angiographic factors. Although others have used less severe stenosis criteria (<50% luminal diameter narrowing), we believe that renal intervention may be more likely considered for patients with significant ARAS. Likewise, since the mortality risk depends highly on the severity of ARAS, significant ARAS should not be mis-diagnosed during coronary intervention via transradial access (White and Olin, 2009). We agree with Babic et al. (2013) that our regression model may be applied in a particular circumstance, and some patients without all risk factors as indicated in our regression model could be suspected for the presence of significant ARAS.

[1]Babic, S., Nezic, D., Radak, D., 2013. Is the routine screening for significant atherosclerotic renal artery stenosis during coronary angiography/intervention indispensable? J. Zhejiang Univ.-Sci. B (Biomed. & Biotechnol.), 14(1):83-84.

[2]Pu, L.J., Shen, Y., Zhang, R.Y., Zhang, Q., Lu, L., Ding, F.H., Hu, J., Yang, Z.K., Shen, W.F., 2012. Screening for significant atherosclerotic renal artery stenosis with a regression model in patients undergoing transradial coronary angiography/intervention. J. Zhejiang Univ.-Sci. B (Biomed. & Biotechnol.), 13(8):631-637.

[3]Scanlon, P.J., Faxon, D.P., Audet, A.M., Carabello, B., Dehmer, G.J., Eagle, K.A., Legako, R.D., Leon, D.F., Murray, J.A., Nissen, S.E., et al., 1999. ACC/AHA guidelines for coronary angiography. A report of the American college of cardiology/American heart association task force on practice guidelines (committee on coronary angiography). Developed in collaboration with the society for cardiac angiography and interventions. J. Am. Coll. Cardiol., 33(6):1756-1824.

[4]White, C.J., Olin, J.W., 2009. Diagnosis and management of atherosclerotic renal artery stenosis: improving patient selection and outcomes. Nat. Clin. Pract. Cardiovasc. Med., 6(3):176-190.