CLC number: R772
On-line Access: 2014-12-03
Received: 2014-03-20
Revision Accepted: 2014-08-30
Crosschecked: 2014-11-14
Cited: 1
Clicked: 7718
Dan Huang, Wen-ya Qiu, Bei Zhang, Bing-hong Wang, Yu-feng Yao. Peripheral deep anterior lamellar keratoplasty using a cryopreserved donor cornea for Terrien’s marginal degeneration[J]. Journal of Zhejiang University Science B, 2014, 15(12): 1055-1063.
@article{title="Peripheral deep anterior lamellar keratoplasty using a cryopreserved donor cornea for Terrien’s marginal degeneration",
author="Dan Huang, Wen-ya Qiu, Bei Zhang, Bing-hong Wang, Yu-feng Yao",
journal="Journal of Zhejiang University Science B",
volume="15",
number="12",
pages="1055-1063",
year="2014",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1400083"
}
%0 Journal Article
%T Peripheral deep anterior lamellar keratoplasty using a cryopreserved donor cornea for Terrien’s marginal degeneration
%A Dan Huang
%A Wen-ya Qiu
%A Bei Zhang
%A Bing-hong Wang
%A Yu-feng Yao
%J Journal of Zhejiang University SCIENCE B
%V 15
%N 12
%P 1055-1063
%@ 1673-1581
%D 2014
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1400083
TY - JOUR
T1 - Peripheral deep anterior lamellar keratoplasty using a cryopreserved donor cornea for Terrien’s marginal degeneration
A1 - Dan Huang
A1 - Wen-ya Qiu
A1 - Bei Zhang
A1 - Bing-hong Wang
A1 - Yu-feng Yao
J0 - Journal of Zhejiang University Science B
VL - 15
IS - 12
SP - 1055
EP - 1063
%@ 1673-1581
Y1 - 2014
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1400083
Abstract: Objective: To evaluate the clinical efficacy of peripheral deep anterior lamellar keratoplasty (DALK) using a cryopreserved donor cornea for terrien’s marginal degeneration (TMD). Methods: Thirty-one eyes of 27 patients with TMD underwent peripheral DALK using cryopreserved donor corneas. According to the distance between the inner edge of the lesion and the limbus, a ring-shaped or D-shaped DALK was performed. All grafts were stored at −20 °C. Cryopreserved corneoscleral rims were prepared for ring-shaped grafts and cryopreserved whole eyeballs were prepared for D-shaped grafts. The general conditions, intraoperative performance, postoperative corneal reconstruction, astigmatism, best corrected visual acuity (BCVA), and various complications were analyzed. Results: Ring-shaped DALK was performed in 28 eyes and D-shaped DALK was performed in 3 eyes. Postoperative follow-up time was (28.4±24.8) months. There was evidence of inflammation before surgery in 12 eyes (38.7%) and intraoperative perforation occurred in 13 eyes (41.9%). The corneal structures of all eyes were reconstructed. Postoperative astigmatism and BCVA showed improvement (both P=0.00) except for cases that underwent D-shaped DALK. Ten eyes (32.2%) developed transient ocular hypertension and one eye (3.2%) developed secondary glaucoma. No primary disease recurrence or corneal allograft rejection was observed. Conclusions: Peripheral DALK for TMD using cryopreserved donor tissue is an effective technique that eliminates rejection and extends the use of donor eyes. Inflammatory history or intraoperative perforation has no adverse effect on graft recovery. However, D-shaped DALK did not achieve good visual outcomes.
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