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Yangqing SHAO, Yitong ZHANG, Wenxuan ZHU, Huasong LU. Biomolecular condensates in Hippo pathway regulation[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="Biomolecular condensates in Hippo pathway regulation",
author="Yangqing SHAO, Yitong ZHANG, Wenxuan ZHU, Huasong LU",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2500092"
}
%0 Journal Article
%T Biomolecular condensates in Hippo pathway regulation
%A Yangqing SHAO
%A Yitong ZHANG
%A Wenxuan ZHU
%A Huasong LU
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
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%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2500092
TY - JOUR
T1 - Biomolecular condensates in Hippo pathway regulation
A1 - Yangqing SHAO
A1 - Yitong ZHANG
A1 - Wenxuan ZHU
A1 - Huasong LU
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2500092
Abstract: Hippo signaling is a highly conserved pathway central to diverse cellular processes. Dysregulation of this pathway not only leads to developmental abnormalities but is also closely related to the occurrence and progression of various cancers. Recent studies have uncovered that, in addition to the classical signaling cascade regulation, biomolecular condensates formed via phase separation play a key role in the spatiotemporal regulation of Hippo signaling. In this review, we provide a summary of the latest research progress on the regulation of the hippo signaling pathway by phase separation, with a particular focus on transcriptional activation mediated by Yes-associated protein (YAP)/transcriptional coactivator with a PDZ-binding domain (TAZ) condensates. Furthermore, we discuss the utility of chemical crosslinking combined with mass spectrometry to analyze the TAZ condensate interactome and examine the role of FUS in modulating the biophysical properties of TAZ condensates, which in turn influences their transcriptional activity and pro-tumorigenic functions. These insights not only advance our understanding of Hippo signaling but also offer new perspectives for therapeutic interventions targeting diseases linked to dysregulated YAP/TAZ activity.
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