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Bio-Design and Manufacturing  2018 Vol.1 No.4 P.254-264

http://doi.org/10.1007/s42242-018-0027-9


Origami meets electrospinning: a new strategy for 3D nanofiber scaffolds


Author(s):  Juqing Song, Guanglin Zhu, Huichang Gao, Lin Wang, Nanying Li, Xuetao Shi, Yingjun Wang

Affiliation(s):  National Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, People’s Republic of China; more

Corresponding email(s):   shxt@scut.edu.cn, imwangyj@163.com

Key Words:  Electrospinning, Origami, 3D construction, Nanofiber scaffold/cells complex


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Juqing Song, Guanglin Zhu, Huichang Gao, Lin Wang, Nanying Li, Xuetao Shi, Yingjun Wang. Origami meets electrospinning: a new strategy for 3D nanofiber scaffolds[J]. Journal of Zhejiang University Science D, 2018, 1(4): 254-264.

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Abstract: 
Inspired by the constitution of things in the natural world, three-dimensional (3D) nanofiber scaffold/cells complex was constructed via the combination of electrospinning technology and origami techniques. The nanofiber boxes prepared by origami provided a limited space for the layer-by-layer nanofiber films, and the human fetal osteoblasts (hFOBs) seeded on the both sides of the nanofiber films were expected to facilitate the bonding of the adjacent nanofiber films through the secretion of extracellular matrix. Specifically, the hFOBs presented 3D distribution in the nanofiber scaffold, and they can stretch across the gaps between the adjacent nanofiber films, forming the cell layers and filling the whole 3D nanofiber scaffold.Eventually,a3Dblockcomposedofelectrospunnanofiberscaffoldandcellswasobtained,whichpossessespotential applications in bone tissue engineering. Interestingly, we also created 3D nanofiber structures that range from simple forms to intricate architectures via origami, indicating that the combination of electrospinning technology and origami techniques is a feasible method for the 3D construction of tissue engineering scaffolds.

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