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Cellular interplay to 3D in vitro microphysiological disease model: cell patterning microbiota–gut–brain axis
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Kamare Alam, Lakshmi Nair, Souvik Mukherjee, Kulwinder Kaur, Manjari Singh, Santanu Kaity, Velayutham Ravichandiran, Sugato Banerjee & Subhadeep Roy. Cellular interplay to 3D in vitro microphysiological disease model: cell patterning microbiota–gut–brain axis[J]. Journal of Zhejiang University Science D, 2024, 7(3): 320-357.
@article{title="Cellular interplay to 3D in vitro microphysiological disease model: cell
patterning microbiota–gut–brain axis",
author="Kamare Alam, Lakshmi Nair, Souvik Mukherjee, Kulwinder Kaur, Manjari Singh, Santanu Kaity, Velayutham Ravichandiran, Sugato Banerjee & Subhadeep Roy",
journal="Journal of Zhejiang University Science D",
volume="7",
number="3",
pages="320-357",
year="2024",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-024-00282-6"
}
%0 Journal Article
%T Cellular interplay to 3D in vitro microphysiological disease model: cell
patterning microbiota–gut–brain axis
%A Kamare Alam
%A Lakshmi Nair
%A Souvik Mukherjee
%A Kulwinder Kaur
%A Manjari Singh
%A Santanu Kaity
%A Velayutham Ravichandiran
%A Sugato Banerjee & Subhadeep Roy
%J Journal of Zhejiang University SCIENCE D
%V 7
%N 3
%P 320-357
%@ 1869-1951
%D 2024
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-024-00282-6
TY - JOUR
T1 - Cellular interplay to 3D in vitro microphysiological disease model: cell
patterning microbiota–gut–brain axis
A1 - Kamare Alam
A1 - Lakshmi Nair
A1 - Souvik Mukherjee
A1 - Kulwinder Kaur
A1 - Manjari Singh
A1 - Santanu Kaity
A1 - Velayutham Ravichandiran
A1 - Sugato Banerjee & Subhadeep Roy
J0 - Journal of Zhejiang University Science D
VL - 7
IS - 3
SP - 320
EP - 357
%@ 1869-1951
Y1 - 2024
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-024-00282-6
Abstract: The microbiota–gut–brain axis (MGBA) has emerged as a key prospect in the bidirectional communication between two major
organ systems: the brain and the gut. Homeostasis between the two organ systems allows the body to function without disease,
whereas dysbiosis has long-standing evidence of etiopathological conditions. The most common communication paths are
the microbial release of metabolites, soluble neurotransmitters, and immune cells. However, each pathway is intertwined with
a complex one. With the emergence of in vitro models and the popularity of three-dimensional (3D) cultures and Transwells,
engineering has become easier for the scientific understanding of neurodegenerative diseases. This paper briefly retraces the
possible communication pathways between the gut microbiome and the brain. It further elaborates on three major diseases:
autism spectrum disorder, Parkinson’s disease, and Alzheimer’s disease, which are prevalent in children and the elderly. These
diseases also decrease patients’ quality of life. Hence, understanding them more deeply with respect to current advances in
in vitro modeling is crucial for understanding the diseases. Remodeling of MGBA in the laboratory uses many molecular
technologies and biomaterial advances. Spheroids and organoids provide a more realistic picture of the cell and tissue structure
than monolayers. Combining them with the transwell system offers the advantage of compartmentalizing the two systems
(apical and basal) while allowing physical and chemical cues between them. Cutting-edge technologies, such as bioprinting
and microfluidic chips, might be the future of in vitro modeling, as they provide dynamicity.
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