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On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
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Temporal and spatial regulation of biomimetic vascularization in 3D-printed skeletal muscles
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Minxuan Jia, Tingting Fan, Tan Jia, Xin Liu, Heng Liu, Qi Gu. Temporal and spatial regulation of biomimetic vascularization in 3D-printed skeletal muscles[J]. Journal of Zhejiang University Science D, 2024, 7(5): 597-610.
@article{title="Temporal and spatial regulation of biomimetic vascularization in 3D-printed skeletal muscles",
author="Minxuan Jia, Tingting Fan, Tan Jia, Xin Liu, Heng Liu, Qi Gu",
journal="Journal of Zhejiang University Science D",
volume="7",
number="5",
pages="597-610",
year="2024",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-024-00315-0"
}
%0 Journal Article
%T Temporal and spatial regulation of biomimetic vascularization in 3D-printed skeletal muscles
%A Minxuan Jia
%A Tingting Fan
%A Tan Jia
%A Xin Liu
%A Heng Liu
%A Qi Gu
%J Journal of Zhejiang University SCIENCE D
%V 7
%N 5
%P 597-610
%@ 1869-1951
%D 2024
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-024-00315-0
TY - JOUR
T1 - Temporal and spatial regulation of biomimetic vascularization in 3D-printed skeletal muscles
A1 - Minxuan Jia
A1 - Tingting Fan
A1 - Tan Jia
A1 - Xin Liu
A1 - Heng Liu
A1 - Qi Gu
J0 - Journal of Zhejiang University Science D
VL - 7
IS - 5
SP - 597
EP - 610
%@ 1869-1951
Y1 - 2024
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-024-00315-0
Abstract: In the intricate skeletal muscle tissue, the symbiotic relationship between myotubes and their supporting vasculature is pivotal in delivering essential oxygen and nutrients. This study explored the complex interplay between skeletal muscle and endothelial cells in the vascularization of muscle tissue. By harnessing the capabilities of three-dimensional (3D) bioprinting and modeling, we developed a novel approach involving the co-construction of endothelial and muscle cells, followed by their subsequent differentiation. Our findings highlight the importance of the interaction dynamics between these two cell types. Notably, introducing endothelial cells during the advanced phases of muscle differentiation enhanced myotube assembly. Moreover, it stimulated the development of the vascular network, paving the way for the early stages of vascularized skeletal muscle development. The methodology proposed in this study indicates the potential for constructing large-scale, physiologically aligned skeletal muscle. Additionally, it highlights the need for exploring the delicate equilibrium and mutual interactions between muscle and endothelial cells. Based on the multicell-type interaction model, we can predict promising pathways for constructing even more intricate tissues or organs.
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