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Microneedles for Non-transdermal Drug Delivery: Design Strategies and Current Applications
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Jinhong Xu, Xiangyi Liao, Danli Chen, Xiuzhuo Jia, Xufeng Niu. Microneedles for Non-transdermal Drug Delivery: Design Strategies and Current Applications[J]. Journal of Zhejiang University Science D, 2016, -1(-1): .
@article{title="Microneedles for Non-transdermal Drug Delivery:
Design Strategies and Current Applications",
author="Jinhong Xu, Xiangyi Liao, Danli Chen, Xiuzhuo Jia, Xufeng Niu",
journal="Journal of Zhejiang University Science D",
volume="-1",
number="-1",
pages="",
year="2016",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-BDMJ-D-23-00352"
}
%0 Journal Article
%T Microneedles for Non-transdermal Drug Delivery:
Design Strategies and Current Applications
%A Jinhong Xu
%A Xiangyi Liao
%A Danli Chen
%A Xiuzhuo Jia
%A Xufeng Niu
%J Journal of Zhejiang University SCIENCE D
%V -1
%N -1
%P
%@ 1673-1581
%D 2016
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-BDMJ-D-23-00352
TY - JOUR
T1 - Microneedles for Non-transdermal Drug Delivery:
Design Strategies and Current Applications
A1 - Jinhong Xu
A1 - Xiangyi Liao
A1 - Danli Chen
A1 - Xiuzhuo Jia
A1 - Xufeng Niu
J0 - Journal of Zhejiang University Science D
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 2016
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-BDMJ-D-23-00352
Abstract: Microneedles (MNs), as an innovative and viable option for drug delivery, has distinct advantages
of non-invasive, painless, stable drug loading, efficient drug permeation, and ideal biocompatibility.
Microneedles are initially used to penetrate the skin surface and obtain transcutaneous drug delivery,
and have achieved a great success in the field. In recent years, the application of MNs has been
introduced into non-transdermal drug delivery, extending to a variety of tissues and organs. This review
captures the fabrication methods for MNs, provides advanced designing strategies of MNs for
achieving controlled drug release mechanism and summarizes current MNs applications delivering
multiple therapeutic agents to the cardiovascular system, oscular tissue, digestive system, oral cavity,
central nervous system and reproductive system. We hope that this article would better guide readers
to design their MNs system according to different situations, including material selection, structure
design, choice of fabrication methods and tissue considerations, so as to determine the optimal
therapeutic regimen towards the target treatment area.
Open peer comments: Debate/Discuss/Question/Opinion
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