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On-line Access: 2022-01-24

Received: 2021-09-15

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Bio-Design and Manufacturing  2022 Vol.5 No.2 P.249-264

http://doi.org/10.1007/s42242-021-00180-1


3D-printed tissue repair patch combining mechanical support and magnetism for controlled skeletal muscle regeneration


Author(s):  Xiaocheng Wang, Ruibo Zhao, Jian Wang, Xinghuan Li, Lijuan Jin, Wenyu Liu, Lifang Yang, Yonghua Zhu & Zhikai Tan

Affiliation(s):  College of Biology, Hunan University, Changsha 410082, China; more

Corresponding email(s):   tanzk@hnu.edu.cn

Key Words:  Functional biomaterials, Magnetic actuation, Myogenic differentiation, Skeletal muscle regeneration, 3D printing


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Xiaocheng Wang, Ruibo Zhao, Jian Wang, Xinghuan Li, Lijuan Jin, Wenyu Liu, Lifang Yang, Yonghua Zhu & Zhikai Tan. 3D-printed tissue repair patch combining mechanical support and magnetism for controlled skeletal muscle regeneration[J]. Journal of Zhejiang University Science D, 2022, 5(2): 249-264.

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author="Xiaocheng Wang, Ruibo Zhao, Jian Wang, Xinghuan Li, Lijuan Jin, Wenyu Liu, Lifang Yang, Yonghua Zhu & Zhikai Tan",
journal="Journal of Zhejiang University Science D",
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year="2022",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-021-00180-1"
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A1 - Wenyu Liu
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Abstract: 
Physical forces, such as magnetic and mechanical stimulation, are known to play a significant role in the regulation of cell response. In the present study, a biomimetic regeneration patch was fabricated using E-jet 3D printing, which integrates mechanical and magnetic stimulation in a biocompatible “one-pot reaction” strategy when combined with a static magnetic field (SMF). The magneto-based therapeutic regeneration patch induced myoblasts to form aligned and multinucleated myotubes, regulated the expression of myogenic-related genes, and activated the p38α mitogen-activated protein kinase pathway via the initiation of myogenic differentiation. To validate the efficiency of the proposed strategy, the regeneration patch was implanted into mice and exposed to a suitable SMF, which resulted in significantly enhanced in vivo skeletal muscle regeneration. The findings demonstrated that appropriate external physical stimulation provides a suitable biophysical microenvironment that is conducive to tissue regeneration. The method used in the present study represents a promising technique to induce the regeneration of damaged skeletal muscle tissue.

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