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Bio-Design and Manufacturing  2022 Vol.5 No.2 P.249-264

http://doi.org/10.1007/s42242-021-00180-1


3D-printed tissue repair patch combining mechanical support and magnetism for controlled skeletal muscle regeneration


Author(s):  Xiaocheng Wang, Ruibo Zhao, Jian Wang, Xinghuan Li, Lijuan Jin, Wenyu Liu, Lifang Yang, Yonghua Zhu & Zhikai Tan

Affiliation(s):  College of Biology, Hunan University, Changsha 410082, China; more

Corresponding email(s):   tanzk@hnu.edu.cn

Key Words:  Functional biomaterials, Magnetic actuation, Myogenic differentiation, Skeletal muscle regeneration, 3D printing


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Xiaocheng Wang, Ruibo Zhao, Jian Wang, Xinghuan Li, Lijuan Jin, Wenyu Liu, Lifang Yang, Yonghua Zhu & Zhikai Tan. 3D-printed tissue repair patch combining mechanical support and magnetism for controlled skeletal muscle regeneration[J]. Journal of Zhejiang University Science D, 2022, 5(2): 249-264.

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author="Xiaocheng Wang, Ruibo Zhao, Jian Wang, Xinghuan Li, Lijuan Jin, Wenyu Liu, Lifang Yang, Yonghua Zhu & Zhikai Tan",
journal="Journal of Zhejiang University Science D",
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pages="249-264",
year="2022",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-021-00180-1"
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%A Wenyu Liu
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Abstract: 
Physical forces, such as magnetic and mechanical stimulation, are known to play a significant role in the regulation of cell response. In the present study, a biomimetic regeneration patch was fabricated using E-jet 3D printing, which integrates mechanical and magnetic stimulation in a biocompatible “one-pot reaction” strategy when combined with a static magnetic field (SMF). The magneto-based therapeutic regeneration patch induced myoblasts to form aligned and multinucleated myotubes, regulated the expression of myogenic-related genes, and activated the p38α mitogen-activated protein kinase pathway via the initiation of myogenic differentiation. To validate the efficiency of the proposed strategy, the regeneration patch was implanted into mice and exposed to a suitable SMF, which resulted in significantly enhanced in vivo skeletal muscle regeneration. The findings demonstrated that appropriate external physical stimulation provides a suitable biophysical microenvironment that is conducive to tissue regeneration. The method used in the present study represents a promising technique to induce the regeneration of damaged skeletal muscle tissue.

湖南大学谭志凯、王小成、中南大学赵瑞波等 | 3D打印的组织再生贴片结合机械支持和磁性调控骨骼肌再生

本研究论文聚焦于设计模拟骨骼肌结构及细胞外基质成分的组织再生贴片,结合静磁场(SMF)以调控骨骼肌的再生。在骨骼肌再生的过程中,有序肌肉纤维的生成以及恢复丢失的细胞外基质提供的结构线索至关重要。为了实现此目标,许多策略都侧重于利用生物材料重建天然骨骼肌的结构组织,特别是肌肉细胞的单轴排列,这对维持骨骼肌的收缩至关重要。在这里,利用E-jet 3D打印技术制备组织再生贴片,结合静态磁场,通过机械和磁刺激调控骨骼肌再生。组织再生贴片结合静磁场能诱导成肌细胞形成定向的多核肌管并通过激活p38α MAPK途径启动肌原性分化。本论文中使用的方法是一种潜在的能够诱导受损骨骼肌组织再生的技术。

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