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On-line Access: 2025-07-30
Received: 2024-08-25
Revision Accepted: 2025-03-03
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Homologous cancer cell membrane-camouflaged natural pH-sensitive chalk for enhanced drug targeting delivery in hepatocellular carcinoma
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Yangbo Zhu,Pengfei Cui,Lijuan Zhao,Qi Ling,Jiayi Qin. Homologous cancer cell membrane-camouflaged natural pH-sensitive chalk for enhanced drug targeting delivery in hepatocellular carcinoma[J]. Journal of Zhejiang University Science D, 2025, 8(4): 609624.
@article{title="Homologous cancer cell membrane-camouflaged natural pH-sensitive chalk
for enhanced drug targeting delivery in hepatocellular carcinoma",
author="Yangbo Zhu,Pengfei Cui,Lijuan Zhao,Qi Ling,Jiayi Qin",
journal="Journal of Zhejiang University Science D",
volume="8",
number="4",
pages="609624",
year="2025",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2400341"
}
%0 Journal Article
%T Homologous cancer cell membrane-camouflaged natural pH-sensitive chalk
for enhanced drug targeting delivery in hepatocellular carcinoma
%A Yangbo Zhu
%A Pengfei Cui
%A Lijuan Zhao
%A Qi Ling
%A Jiayi Qin
%J Journal of Zhejiang University SCIENCE D
%V 8
%N 4
%P 609624
%@ 1869-1951
%D 2025
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2400341
TY - JOUR
T1 - Homologous cancer cell membrane-camouflaged natural pH-sensitive chalk
for enhanced drug targeting delivery in hepatocellular carcinoma
A1 - Yangbo Zhu
A1 - Pengfei Cui
A1 - Lijuan Zhao
A1 - Qi Ling
A1 - Jiayi Qin
J0 - Journal of Zhejiang University Science D
VL - 8
IS - 4
SP - 609624
EP -
%@ 1869-1951
Y1 - 2025
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2400341
Abstract: The therapeutic efficacy of hepatocellular carcinoma (HCC) medication is severely compromised by inadequate drug deliv?
ery to tumor sites. Herein, we fabricated a biomimetic nanoplatform for improved drug targeting ability by wrapping H22
tumor cell membranes around natural chalk to encapsulate the model drug doxorubicin (C-DOX@H22 CM). When camou?
flaged with H22 tumor cell membranes, C-DOX@H22 CM achieved primary targeting to the tumor tissues due to the
immune escape ability and secondary deep targeting to HCC cells owing to the homologous targeting properties. The cellular
uptake of C-DOX@H22 CM by H22 cells was via clathrin-mediated endocytosis. Meanwhile, C-DOX@H22 CM exhibited
the property of deep penetration into dense tumor tissues. Moreover, the pH-responsive characteristics of the natural chalk
enabled C-DOX@H22 CM to achieve endosomal escape and drug release, thereby expanding its antitumor effects without
compromising biocompatibility. Importantly, the in vivo experiments also confirmed that C-DOX@H22 CM had favorable
antitumor efficacy and biosafety in the H22 tumor-bearing mouse model. Overall, the novel C-DOX@H22 CM nanoplat?
form provides a safe and effective treatment option for HCC and has the potential to achieve clinical translation for the tar?
geted delivery of other drugs for the treatment of various tumors.
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