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On-line Access: 2026-03-26
Received: 2025-07-10
Revision Accepted: 2025-11-14
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An integrated cartilage-on-a-chip recapitulating the bio-chemo-mechanical microenvironment in osteoarthritic joints
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Hongxing Jia. An integrated cartilage-on-a-chip recapitulating the bio-chemo-mechanical microenvironment in osteoarthritic joints[J]. Journal of Zhejiang University Science D, 2026, 9(2): 357 - 378.
@article{title="An integrated cartilage-on-a-chip recapitulating the bio-chemo-mechanical microenvironment in osteoarthritic joints",
author="Hongxing Jia",
journal="Journal of Zhejiang University Science D",
volume="9",
number="2",
pages="357 - 378",
year="2026",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2500348"
}
%0 Journal Article
%T An integrated cartilage-on-a-chip recapitulating the bio-chemo-mechanical microenvironment in osteoarthritic joints
%A Hongxing Jia
%J Journal of Zhejiang University SCIENCE D
%V 9
%N 2
%P 357 - 378
%@ 1869-1951
%D 2026
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2500348
TY - JOUR
T1 - An integrated cartilage-on-a-chip recapitulating the bio-chemo-mechanical microenvironment in osteoarthritic joints
A1 - Hongxing Jia
J0 - Journal of Zhejiang University Science D
VL - 9
IS - 2
SP - 357
EP - 378
%@ 1869-1951
Y1 - 2026
PB - Zhejiang University Press & Springer
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DOI - 10.1631/bdm.2500348
Abstract: osteoarthritis (OA), the most common chronic joint disease, leads to remarkable morbidity and disability. The development of preclinical models that accurately recapitulate the bio-chemo-mechanical microenvironment of osteoarthritic joints is crucial for elucidating OA pathogenesis and facilitating drug development. In this study, we present a microfluidics-based cartilage-on-a-chip model that integrates tunable mechanical stimulation and inter-tissue/cell communication, mimicking the key physiological characteristics of articular cartilage for organ-level OA research. By applying controllable mechanical compression, we established a model that captures healthy and injury hallmarks of the cartilage and directly observed the mechanotransduction responses in chondrocytes. We further demonstrated that mechanically damaged cartilage induces synovial abnormalities and immune dysregulation and explored the potential of our chip as a platform for screening therapeutic targets. This cartilage-on-a-chip offers an in vitro system with a close-to-in vivo microenvironment for investigating complex bio-chemo-mechanical interactions, paving the way for advanced studies on OA pathogenesis and drug screening.
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