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Subcutaneous microfuse-activated device for programmed pulsatile drug delivery
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Myoung Ju Kim, Han Bi Ji, Yong Chan Cho, Jae Chan Cho, Woo Hyun Kim, Gi Min Park, Chang Hee Min, Min Ji Kim, Cho Rim Kim, Jae Hoon Han, Cheol Lee, Mark R. Prausnitz, Young Bin Choy. Subcutaneous microfuse-activated device for programmed pulsatile drug delivery[J]. Journal of Zhejiang University Science D, 2026, 9(3): 599 - 611.
@article{title="Subcutaneous microfuse-activated device for programmed pulsatile drug delivery",
author="Myoung Ju Kim, Han Bi Ji, Yong Chan Cho, Jae Chan Cho, Woo Hyun Kim, Gi Min Park, Chang Hee Min, Min Ji Kim, Cho Rim Kim, Jae Hoon Han, Cheol Lee, Mark R. Prausnitz, Young Bin Choy",
journal="Journal of Zhejiang University Science D",
volume="9",
number="3",
pages="599 - 611",
year="2026",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2500511"
}
%0 Journal Article
%T Subcutaneous microfuse-activated device for programmed pulsatile drug delivery
%A Myoung Ju Kim
%A Han Bi Ji
%A Yong Chan Cho
%A Jae Chan Cho
%A Woo Hyun Kim
%A Gi Min Park
%A Chang Hee Min
%A Min Ji Kim
%A Cho Rim Kim
%A Jae Hoon Han
%A Cheol Lee
%A Mark R. Prausnitz
%A Young Bin Choy
%J Journal of Zhejiang University SCIENCE D
%V 9
%N 3
%P 599 - 611
%@ 1869-1951
%D 2026
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2500511
TY - JOUR
T1 - Subcutaneous microfuse-activated device for programmed pulsatile drug delivery
A1 - Myoung Ju Kim
A1 - Han Bi Ji
A1 - Yong Chan Cho
A1 - Jae Chan Cho
A1 - Woo Hyun Kim
A1 - Gi Min Park
A1 - Chang Hee Min
A1 - Min Ji Kim
A1 - Cho Rim Kim
A1 - Jae Hoon Han
A1 - Cheol Lee
A1 - Mark R. Prausnitz
A1 - Young Bin Choy
J0 - Journal of Zhejiang University Science D
VL - 9
IS - 3
SP - 599
EP - 611
%@ 1869-1951
Y1 - 2026
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2500511
Abstract: Pulsatile drug delivery, in which rapid drug release is separated by defined lag periods, offers significant therapeutic advantages but is limited by the need for repeated injections and poor patient adherence. Here, we introduce the fused device (FUSED), a subcutaneous system enabling programmed multidose drug delivery through a single implantation. FUSED comprises paired delay and shot units that regulate dosing intervals and trigger pulsatile drug release, respectively. After implantation, body fluids gradually dissolve the microfuse in each delay unit, with the delay duration determined by fuse length. Once fluid reaches a shot unit, an effervescent reaction is initiated, producing rapid drug release. In vitro and in vivo evaluations demonstrated precise pulsatile release of the model antigen ovalbumin, effectively reproducing prime–boost vaccination timing and eliciting the corresponding immune response. These results suggest that FUSED may provide a viable alternative to repeated injections and improve adherence in multidose therapeutic regimens.The alternative text for this image may have been generated using AI.
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CLC number:
On-line Access: 2026-04-28
Received: 2025-10-07
Revision Accepted: 2026-01-12
Crosschecked: 0000-00-00
Cited:
Clicked: 829
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