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EXPRESSION OF TGF-β1 AND TGF-β R II IN COLORECTAL ADENOMAS OF VARYING STAGES
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WANG Da, HE Chao, DING Wei, WANG Hui-ping. EXPRESSION OF TGF-β1 AND TGF-β R II IN COLORECTAL ADENOMAS OF VARYING STAGES[J]. Journal of Zhejiang University Science A, 2001, 2(1): 107-110.
@article{title="EXPRESSION OF TGF-β1 AND TGF-β R II IN COLORECTAL ADENOMAS OF VARYING STAGES",
author="WANG Da, HE Chao, DING Wei, WANG Hui-ping",
journal="Journal of Zhejiang University Science A",
volume="2",
number="1",
pages="107-110",
year="2001",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2001.0107"
}
%0 Journal Article
%T EXPRESSION OF TGF-β1 AND TGF-β R II IN COLORECTAL ADENOMAS OF VARYING STAGES
%A WANG Da
%A HE Chao
%A DING Wei
%A WANG Hui-ping
%J Journal of Zhejiang University SCIENCE A
%V 2
%N 1
%P 107-110
%@ 1869-1951
%D 2001
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2001.0107
TY - JOUR
T1 - EXPRESSION OF TGF-β1 AND TGF-β R II IN COLORECTAL ADENOMAS OF VARYING STAGES
A1 - WANG Da
A1 - HE Chao
A1 - DING Wei
A1 - WANG Hui-ping
J0 - Journal of Zhejiang University Science A
VL - 2
IS - 1
SP - 107
EP - 110
%@ 1869-1951
Y1 - 2001
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2001.0107
Abstract: To study the function of transforming growth factor β1 (TGF-&beta%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>TGF-β1) and transforming growth factor-β type II receptor (TGF-&beta%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>TGF-βr II) in varying stages of colorectal adenoma during neoplastic transformation, fifty-five cases of resected colorectal adenomas were examined immunohistochemically. Our results showed that the expression of TGF-&beta%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>TGF-β1 ranged from high to low, with the progression of low-grade to high-grade dysplasia of adenomas to carcinoma. And there was significantly different expression of TGF-&beta%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>TGF-β1 between moderate and high dysplasia adenomas (P<0.05), but no significantly different expression of TGF-&beta%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>TGF-β r II was found among varying stages of adenomas. Our results suggested that the quantities of TGF-&beta%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>TGF-β1 secreted by adenoma cells decrease dramatically in moderate to severe dysplasia colorectal adenomas. It is the decreased secretion of TGF-&beta%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>TGF-β1, rather than the mutated TGF-&beta%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>TGF-βr II that may play an important role in transforming colorectal adenomas to adenocarcinomas.
[1] Brattain,M.G.,Markowitz,S.D.,Willson,S.K.et al.,1996.The type II transforming growth factor-beta receptor as a tumor-suppressor gene.Curr Opin Oncol.8(1):49-53.
[2] Coffey,R.,Goustin,A.,Mangelsdorf-Soderqvist,A.et al.,1987.Transforming growth factor α and β expression in human colon cancer lines: Implications for an autocrine model.Cancer Res.47:4590-4594.
[3] Eskinazi,R.,Resibois,A.,Svoboda,M.et al.,1998.Expression of Transforming Growth Factor β receptors in normal human colon and sporadic adenocarcinomas.Gastroenterology.114: 1211-1220.
[4] Guan,G.X.,Zhang,X.F.,Yang,F.D.et al.,1998.Expression of Transforming Growth Factor β type II receptor in colorectal cancers and precancerous lesions.Chin J Pathol.27(4):306-307.
[5] Laethem,J-L.V.,Resibois,A.,Adler,M.et al.,1996.Localization of Transforming Growth Factor-β1 precursor and latent TGF-β1 binding protein in colorectal adenomas.Dig Dis Sci.41(9):1741-1748.
[6] Lahm,H.,Odartchenko,N.,1993.Role of transforming growth factor β in colorectal cancer.Growth Factors.9:1-9.
[7] Manning,A.M.,Williams,A.C.,Game,S.M.et al.,1991.Differential sensitivity of human colonic adenoma and carcinoma cells to transforming growth factor β(TGFβ): conversion of an adenoma cell line to a tumorigenic phenotype is accompanied by a reduced response to the inhibitory effect of TGF-β.Oncogene.6:1471-1476.
[8] Matsushita,M.,Matsuzaki,K.,Date,M.et al.,1999.Down-regulation of TGF-β receptors in human colorectal cancer: implications for cancer development.Br J Cancer.80:194-205.
[9] Muto,T.,Bussey,H.J.R.,Morson,B.C.,1975.The evolution of cancer of the colon and rectum.Cancer.36:2251-2270.
[10] Tsushima,H.,Kawata,S.,Tamura,S.et al.,1996.High levels of transforming growth factor β1 in patients with colorectal cancer: association with disease progression.Gastroenterology.110:375-382.
[11] Zhu,Z.W.,Zeng,L.F.,Wang,Y.C.et al.,1996.The expressions and changes of TGF-α,β genes in human cancerous,paracancerous and normal colorectum mucosal tissues.Acta Anatomical Sinica.27(3):290-294.
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