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Journal of Zhejiang University SCIENCE A 2004 Vol.5 No.8 P.956-959


Cleaner and convenient preparation of 3-(4,6-dimethoxy-pyrimidin-2-yloxy)-2-methyl-phenol

Author(s):  WEN Yue-zhong, FANG Zhao-hua, LIU Wei-ping

Affiliation(s):  Institute of Environmental Science, College of Environmental & Resource Sciences, Zhejiang University, Hangzhou 310029, China

Corresponding email(s):   wenyuezhong@zjuem.zju.edu.cn

Key Words:  Cleaner preparation, Greener technology, Selective synthesis, 2-methyl-benzene-1, 3-diol, 3-(4, 6-dimethoxy-pyrimidin-2-yloxy)-2-methyl-phenol

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WEN Yue-zhong, FANG Zhao-hua, LIU Wei-ping. Cleaner and convenient preparation of 3-(4,6-dimethoxy-pyrimidin-2-yloxy)-2-methyl-phenol[J]. Journal of Zhejiang University Science A, 2004, 5(8): 956-959.

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Environmental concerns have highlighted the need of cleaner technologies. A cleaner, convenient and selective technology has been developed for the preparation of 3-(4,6-dimethoxy-pyrimidin-2-yloxy)-2-methyl-phenol (DPMP) from 2-methyl-benzene-1,3-diol in water as solvent. The isolated yield of DPMP is up to 86% in good selectivity. The product structure was characterized by conventional methods, 1H-NMR and MS. This technology belongs to the modern concept of environmentally friendly low wastes or non-wastes technology (LWNWT).

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