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CLC number: TN911.73

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Received: 2003-07-21

Revision Accepted: 2003-09-21

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Journal of Zhejiang University SCIENCE A 2004 Vol.5 No.12 P.1621-1628


Enhancing the quality metric of protein microarray image

Author(s):  WANG Li-qiang, NI Xu-xiang, LU Zu-kang, ZHENG Xu-feng, LI Ying-sheng

Affiliation(s):  State Key Lab of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, China

Corresponding email(s):   wangliqiang@zju.edu.cn

Key Words:  Protein microarray, Image enhancement, Filter, Noise

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WANG Li-qiang, NI Xu-xiang, LU Zu-kang, ZHENG Xu-feng, LI Ying-sheng. Enhancing the quality metric of protein microarray image[J]. Journal of Zhejiang University Science A, 2004, 5(12): 1621-1628.

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T1 - Enhancing the quality metric of protein microarray image
A1 - WANG Li-qiang
A1 - NI Xu-xiang
A1 - LU Zu-kang
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.2004.1621

The novel method of improving the quality metric of protein microarray image presented in this paper reduces impulse noise by using an adaptive median filter that employs the switching scheme based on local statistics characters; and achieves the impulse detection by using the difference between the standard deviation of the pixels within the filter window and the current pixel of concern. It also uses a top-hat filter to correct the background variation. In order to decrease time consumption, the top-hat filter core is cross structure. The experimental results showed that, for a protein microarray image contaminated by impulse noise and with slow background variation, the new method can significantly increase the sig-nal-to-noise ratio, correct the trends in the background, and enhance the flatness of the background, the consistency of the signal intensity.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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