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Journal of Zhejiang University SCIENCE B 2005 Vol.6 No.5 P.446-450


Pharmacokinetics of gemcitabine in Chinese patients with non-small-cell lung cancer

Author(s):  WANG Lin-run, HUANG Ming-zhu, XU Nong, SHENTU Jian-zhong, LIU Jian, CAI Jie

Affiliation(s):  First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China

Corresponding email(s):   linrunw@yahoo.com.cn

Key Words:  Gemcitabine, Non-small-cell lung cancer, Pharmacokinetics

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WANG Lin-run, HUANG Ming-zhu, XU Nong, SHENTU Jian-zhong, LIU Jian, CAI Jie. Pharmacokinetics of gemcitabine in Chinese patients with non-small-cell lung cancer[J]. Journal of Zhejiang University Science B, 2005, 6(5): 446-450.

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author="WANG Lin-run, HUANG Ming-zhu, XU Nong, SHENTU Jian-zhong, LIU Jian, CAI Jie",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%T Pharmacokinetics of gemcitabine in Chinese patients with non-small-cell lung cancer
%A WANG Lin-run
%A HUANG Ming-zhu
%A XU Nong
%A SHENTU Jian-zhong
%A LIU Jian
%A CAI Jie
%J Journal of Zhejiang University SCIENCE B
%V 6
%N 5
%P 446-450
%@ 1673-1581
%D 2005
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2005.B0446

T1 - Pharmacokinetics of gemcitabine in Chinese patients with non-small-cell lung cancer
A1 - WANG Lin-run
A1 - HUANG Ming-zhu
A1 - XU Nong
A1 - SHENTU Jian-zhong
A1 - LIU Jian
A1 - CAI Jie
J0 - Journal of Zhejiang University Science B
VL - 6
IS - 5
SP - 446
EP - 450
%@ 1673-1581
Y1 - 2005
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2005.B0446

To determine the pharmacokinetics of gemcitabine (2′,2′-difluorodeoxycytidine) in Chinese non-small-cell lung cancer (NSCLC) patients. Six study subjects were administered gemcitabine at a fixed dose rate of 10 mg/m2 per min (1200 mg/m2, two hours infusion), and carboplatin and plasma gemcitabine concentrations were measured by ion-pair reversed-phase high-performance liquid chromatography (HPLC). 3P97 Pharmaceutical Kinetics Software was used for the calculation of pharmacokinetic parameters. The obtained mean parameters, elimnation half life (t1/2) (10.67±3.38 min), area under the curve (AUC) (7.55±1.53 (µg·h)/ml), and clearance (CL) (3940.05±672.08 ml/min), were consistent with those reported in literature. The hematologic toxicology result showed that the regimen was effective on and tolerated by the patients.

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