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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.3 P.179-191


Role of LINC00152 in non-small cell lung cancer

Author(s):  Hong Yu, Shu-Bin Li

Affiliation(s):  Cell Biology Laboratory, Jilin Province Institute of Cancer Prevention and Treatment, Jilin Cancer Hospital, Changchun 130012, China; more

Corresponding email(s):   lshbbj@126.com

Key Words:  Long non-coding RNA, LINC00152, Non-small cell lung cancer, Proliferation, Prognosis

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Hong Yu, Shu-Bin Li. Role of LINC00152 in non-small cell lung cancer[J]. Journal of Zhejiang University Science B, 2020, 21(3): 179-191.

@article{title="Role of LINC00152 in non-small cell lung cancer",
author="Hong Yu, Shu-Bin Li",
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publisher="Zhejiang University Press & Springer",

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%T Role of LINC00152 in non-small cell lung cancer
%A Hong Yu
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1900312

T1 - Role of LINC00152 in non-small cell lung cancer
A1 - Hong Yu
A1 - Shu-Bin Li
J0 - Journal of Zhejiang University Science B
VL - 21
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SP - 179
EP - 191
%@ 1673-1581
Y1 - 2020
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1900312

non-small cell lung cancer (NSCLC) accounts for about 85% of all lung cancer cases. The pathogenesis of NSCLC involves complex gene networks that include different types of non-coding RNAs, such as long non-coding RNAs (lncRNAs). The role of lncRNAs in NSCLC is gaining an increasing interest as their function is being explored in various human cancers. Recently, a new oncogenic lncRNA, LINC00152 (cytoskeleton regulator RNA (CYTOR)), has been identified in different tumor types. In NSCLC, the high expression of LINC00152 in tumor tissue and peripheral blood samples has been shown to be associated with worse prognoses of NSCLC patients. Overexpression of LINC00152 has been confirmed to promote the proliferation, invasion, and migration of NSCLC cells in vitro, as well as increase tumor growth in vivo. This review discusses the role of LINC00152 in NSCLC.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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