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Received: 2005-11-22

Revision Accepted: 2005-12-26

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Journal of Zhejiang University SCIENCE B 2006 Vol.7 No.2 P.164-164


Human cancer genetics

Author(s):  Li Marilyn, Albertson Donna

Affiliation(s):  Medical School, Tulane University, New Orleans, LA 70112-2699, USA; more

Corresponding email(s):   mli2@tulane.edu, albertson@cc.ucsf.edu

Key Words:  Cancer genetics, Oncogenes, Tumor suppress genes, Microarray CGH (comparative genomic hybridization), Presymptomatic testing

Li Marilyn, Albertson Donna. Human cancer genetics[J]. Journal of Zhejiang University Science B, 2006, 7(2): 164-164.

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The short report will be focused on the genetic basis and possible mechanisms of tumorigenesis, common types of cancer, the importance of genetic diagnosis of cancer, and the methodology of cancer genetic diagnosis. They will also review presymptomatic testing of hereditary cancers, and the application of expression profiling to identify patients likely to benefit from particular therapeutic approaches.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


[1] Jiang, G.C., Young, F., Li, M., Weissbecker, K., Price, S., Kim, K.C., Rice, J., La Russa, V.F., Safah, H., Ehrlich, M., 2003. Imtinib (STI571) provides only limited selectivity for CML cells and treatment might be complicated by silent SCR/ABL genes. Cancer Biology & Therapy, 2(1):166/1-166/7.

[2] Kops, G.J., Weaver, B.A., Cleveland, D.W., 2005. On the road to cancer: aneuploidy and the mitotic checkpoint. Nat. Rev. Cancer, 5(10):773-785.

[3] Pinkel, D., Albertson, D.G., 2005. Array comparative genomic hybridization and its applications in cancer. Nat. Genet., 37(Suppl 6):S11-S17.

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