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CLC number: R735.8

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Received: 2006-04-27

Revision Accepted: 2006-07-10

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Journal of Zhejiang University SCIENCE B 2006 Vol.7 No.9 P.719-724

http://doi.org/10.1631/jzus.2006.B0719


Successful immunological treatment of gallbladder cancer in India―Case report


Author(s):  KHAN Jamal A., YAQIN Sharmin

Affiliation(s):  Microbiology Research Lab, C-38/Sector 20, Noida Zip 201301, India

Corresponding email(s):   cancerclinic2000@yahoo.com

Key Words:  Gallbladder, Cancer, Dendritic cell, Immunotherapy


KHAN Jamal A., YAQIN Sharmin. Successful immunological treatment of gallbladder cancer in India―Case report[J]. Journal of Zhejiang University Science B, 2006, 7(9): 719-724.

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author="KHAN Jamal A., YAQIN Sharmin",
journal="Journal of Zhejiang University Science B",
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doi="10.1631/jzus.2006.B0719"
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%T Successful immunological treatment of gallbladder cancer in India―Case report
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%DOI 10.1631/jzus.2006.B0719

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T1 - Successful immunological treatment of gallbladder cancer in India―Case report
A1 - KHAN Jamal A.
A1 - YAQIN Sharmin
J0 - Journal of Zhejiang University Science B
VL - 7
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EP - 724
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.2006.B0719


Abstract: 
gallbladder cancer has a poor outcome because of its anatomy and location. Often, the diagnosis is made very late due to its silent course. Post-operated cases do respond to chemotherapy but the survival is counted in months and the quality of life is further hampered due to toxicity of drugs. immunotherapy holds good promise in non-responding cancers treated by conventional chemotherapeutic agents. Among various therapies, dendritic cell therapy is growing at rapid pace due to its acceptable rationale. It has been utilized in treating successfully resected stage III (T2, N1, M0) gallbladder cancer in one of our patients. A 48 years old lady treated with this therapy is free of metastasis with ten doses of autologous dendritic cell vaccine constructed by utilizing resected tumor lysate antigen. She has received ten doses of therapy in 14 months of her treatment. This therapy has proven to be safe and without apparent side effects. The positive clinical response obtained supports that autologous dendritic cell-based immunotherapy is a promising therapeutic approach for refractory gallbladder cancers.

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Reference

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