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CLC number: R730.264

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Received: 2005-11-18

Revision Accepted: 2005-12-13

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Journal of Zhejiang University SCIENCE B 2006 Vol.7 No.2 P.114-117

http://doi.org/10.1631/jzus.2006.B0114


Dendritic cell therapy with improved outcome in glioma multiforme―a case report


Author(s):  Khan Jamal A., Yaqin Sharmin

Affiliation(s):  Microbiology Research Lab, C-38/Sector 20, Noida U.P., 201301, India

Corresponding email(s):   cancerclinic2000@yahoo.com

Key Words:  Dendritic cells, Glioma, Immunetherapy


Khan Jamal A., Yaqin Sharmin. Dendritic cell therapy with improved outcome in glioma multiforme―a case report[J]. Journal of Zhejiang University Science B, 2006, 7(2): 114-117.

@article{title="Dendritic cell therapy with improved outcome in glioma multiforme―a case report",
author="Khan Jamal A., Yaqin Sharmin",
journal="Journal of Zhejiang University Science B",
volume="7",
number="2",
pages="114-117",
year="2006",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2006.B0114"
}

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%T Dendritic cell therapy with improved outcome in glioma multiforme―a case report
%A Khan Jamal A.
%A Yaqin Sharmin
%J Journal of Zhejiang University SCIENCE B
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%P 114-117
%@ 1673-1581
%D 2006
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2006.B0114

TY - JOUR
T1 - Dendritic cell therapy with improved outcome in glioma multiforme―a case report
A1 - Khan Jamal A.
A1 - Yaqin Sharmin
J0 - Journal of Zhejiang University Science B
VL - 7
IS - 2
SP - 114
EP - 117
%@ 1673-1581
Y1 - 2006
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2006.B0114


Abstract: 
Malignant gliomas are the most devastating tumors in clinical practice and have poorest survival. Immunological treatment of such patients may likely increase the survival and quality of life. dendritic cells (DCs), most potent antigen presenting cells in combination with oral chemotherapeutic agents may be tried for patients giving consent to such treatment. We have successfully combined the two therapies in an adult male patient who was on downhill course after being operated on once with post operation chemotherapy and radiotherapy for glioma in the left parietal area. He received five dendritic cell therapy vaccines in combination with oral chemotherapy and responded dramatically having near normal quality of life for an additional five months with this regime, increasing the survival after operation to 11 months. This therapy is continuing with radiological betterment of the lesion. The DCs are matured with antigen extracted from wax embedded tissue at 6th day of culture. We feel that the treatment can be given to more number of patients to establish its efficacy for the dreaded cancer glioblastoma multiforme.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

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