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Journal of Zhejiang University SCIENCE B 2009 Vol.10 No.4 P.280-284


Persistence of gentamicin residues in milk after the intramammary treatment of lactating cows for mastitis

Author(s):  Xun TAN, Ye-wen JIANG, Yi-jun HUANG, Song-hua HU

Affiliation(s):  Department of Veterinary Medicine, Zhejiang University, Hangzhou 310029, China

Corresponding email(s):   songhua@zju.edu.cn

Key Words:  Gentamicin, Mastitis, Intramammary infusion, Residue

Xun TAN, Ye-wen JIANG, Yi-jun HUANG, Song-hua HU. Persistence of gentamicin residues in milk after the intramammary treatment of lactating cows for mastitis[J]. Journal of Zhejiang University Science B, 2009, 10(4): 280-284.

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author="Xun TAN, Ye-wen JIANG, Yi-jun HUANG, Song-hua HU",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%T Persistence of gentamicin residues in milk after the intramammary treatment of lactating cows for mastitis
%A Xun TAN
%A Ye-wen JIANG
%A Yi-jun HUANG
%A Song-hua HU
%J Journal of Zhejiang University SCIENCE B
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%P 280-284
%@ 1673-1581
%D 2009
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0820198

T1 - Persistence of gentamicin residues in milk after the intramammary treatment of lactating cows for mastitis
A1 - Xun TAN
A1 - Ye-wen JIANG
A1 - Yi-jun HUANG
A1 - Song-hua HU
J0 - Journal of Zhejiang University Science B
VL - 10
IS - 4
SP - 280
EP - 284
%@ 1673-1581
Y1 - 2009
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0820198

This study was designed to investigate persistence of gentamicin residues in milk after the intramammary treatment of lactating cows for mastitis. Milk samples were collected at a 1-d interval after the last administration from 34 individual cows that had received intramammary infusions of gentamicin. The doses and treatment times evaluated in this study represented those that have been applied by veterinarians in practice. The tetrazolium chloride assay was used to determine whether there were significant residues of the antibiotic in the samples. Persistence of detectable drug residues in milk from 33 cows (28 cows, ≤6 infusions at ≤0.7 g gentamicin; and 5 cows, 2 infusions at 0.8 g gentamicin) did not exceed 5 d; but 1 cow (5 infusions at 0.8 g gentamicin) had detectable residues in its milk for 9 d. Our results suggest that a 5-d milk withdrawal period might be insufficient to secure the clearance of the contamination of gentamicin, because treatment times and dosages contribute to the antibiotic clearance. A larger scale of samples are needed for further investigations.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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