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Journal of Zhejiang University SCIENCE B 2009 Vol.10 No.3 P.219-229


Colorectal cancer, one entity or three

Author(s):  Feng-ying LI, Mao-de LAI

Affiliation(s):  Department of Pathology, School of Medicine, Zhejiang University, Hangzhou 310058, China

Corresponding email(s):   lmd@zju.edu.cn

Key Words:  Colorectal cancer, Proximal colon, Distal colon, Rectum, Carcinogenesis, Epidemiology and prognosis

Feng-ying LI, Mao-de LAI. Colorectal cancer, one entity or three[J]. Journal of Zhejiang University Science B, 2009, 10(3): 219-229.

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publisher="Zhejiang University Press & Springer",

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T1 - Colorectal cancer, one entity or three
A1 - Feng-ying LI
A1 - Mao-de LAI
J0 - Journal of Zhejiang University Science B
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B0820273

Understanding of the mechanism of colorectal carcinogenesis has been gaining momentum for some years on account of its high incidence and impact on the lives of individuals affected. Different genetic abnormalities have been found in colorectal cancers from different sites. For example, proximal colon cancer is usually related to the nucleotide instability pathway, as microsatellite instability (MSI). However, distal colon cancer is usually associated with specific chromosomal instability (CIN). The development of cancer at the rectum, though similar to that at the colon, displays its own unique features. These differences might be partially attributed to different embryological development and physiological circumstances. Environmental factors such as diet and alcohol intake also differ in their role in the development of tumors in the three segments, proximal colon, distal colon, and rectum. “Proximal shift” of colon cancer has been known for some time, and survival rates of colorectal cancer are higher when rectal cancers are excluded, both of which emphasize the three different segments of colorectal cancer and their different properties. Meanwhile, colonic and rectal cancers are distinctive therapeutic entities. The concept of three entities of colorectal cancer may be important in designing clinical trails or therapeutic strategies. However, the dispute about the inconsistency of data concerning the site-specific mechanism of colorectal carcinoma does exist, and more evidence about molecular events of carcinogenesis and targeted therapy needs to be collected to definitely confirm the conception.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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