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Received: 2009-11-29

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Journal of Zhejiang University SCIENCE B 2010 Vol.11 No.4 P.258-266

http://doi.org/10.1631/jzus.B0900383


RegIV expression showing specificity to gastrointestinal tract and its potential role in diagnosing digestive tract neuroendocrine tumor


Author(s):  Feng-ying Li, Xiao-bin Ren, En-ping Xu, Qiong Huang, Hong-qiang Sheng, Bing-jian Lv, Mao-de Lai

Affiliation(s):  Department of Pathology, School of Medicine, Zhejiang University, Hangzhou 310058, China, Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China, Department of Epidemiology and Biostatistics, School of Medicine, Zhejiang University, Hangzhou 310058, China, Anatomical and Cellular Pathology, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China

Corresponding email(s):   lmd@zju.edu.cn

Key Words:  Colorectal cancer, Expression profile, Neuroendocrine tumor, Regenerating gene IV (RegIV) An erratum to this article can be found at doi:10.1631/jzus.B09e0383


Feng-ying Li, Xiao-bin Ren, En-ping Xu, Qiong Huang, Hong-qiang Sheng, Bing-jian Lv, Mao-de Lai. RegIV expression showing specificity to gastrointestinal tract and its potential role in diagnosing digestive tract neuroendocrine tumor[J]. Journal of Zhejiang University Science B, 2010, 11(4): 258-266.

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author="Feng-ying Li, Xiao-bin Ren, En-ping Xu, Qiong Huang, Hong-qiang Sheng, Bing-jian Lv, Mao-de Lai",
journal="Journal of Zhejiang University Science B",
volume="11",
number="4",
pages="258-266",
year="2010",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B0900383"
}

%0 Journal Article
%T RegIV expression showing specificity to gastrointestinal tract and its potential role in diagnosing digestive tract neuroendocrine tumor
%A Feng-ying Li
%A Xiao-bin Ren
%A En-ping Xu
%A Qiong Huang
%A Hong-qiang Sheng
%A Bing-jian Lv
%A Mao-de Lai
%J Journal of Zhejiang University SCIENCE B
%V 11
%N 4
%P 258-266
%@ 1673-1581
%D 2010
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0900383

TY - JOUR
T1 - RegIV expression showing specificity to gastrointestinal tract and its potential role in diagnosing digestive tract neuroendocrine tumor
A1 - Feng-ying Li
A1 - Xiao-bin Ren
A1 - En-ping Xu
A1 - Qiong Huang
A1 - Hong-qiang Sheng
A1 - Bing-jian Lv
A1 - Mao-de Lai
J0 - Journal of Zhejiang University Science B
VL - 11
IS - 4
SP - 258
EP - 266
%@ 1673-1581
Y1 - 2010
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0900383


Abstract: 
Regenerating gene IV (RegIV), a member of the regenerating gene family discovered in 2001, has been found to be involved in malignancy in several different organs including the stomach, colorectum, pancreas and prostate, but the overall expression profile of RegIV has not been reported. To learn more about RegIV, we evaluated its distribution by immunohistochemistry (IHC) in a total of 360 samples including 24 types of normal tissue, 40 benign and malignant lesions, and 18 neuroendocrine tumors. We found that in normal tissues, in addition to its relative specificity for the gastrointestinal tract, RegIV was detected in the adrenal gland and mammary gland. Among all the malignancies of various histological types under evaluation, RegIV was found mostly in adenocarcinomas. Studies on additional sets of colorectal tumor samples showed that RegIV expression was predominant in colorectal adenoma (87.5%) and peritumoral tissue (100%) but not in cancer tissue (30.8%). Among neuroendocrine tumors, RegIV had a relatively restricted expression to those of digestive system.

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Reference

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