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CLC number: R587.1

On-line Access: 2010-11-04

Received: 2010-03-08

Revision Accepted: 2010-09-01

Crosschecked: 2010-10-19

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Journal of Zhejiang University SCIENCE B 2010 Vol.11 No.11 P.848-850

http://doi.org/10.1631/jzus.B1000080


Fulminant type 1 diabetes in China: a case report and review of the literature


Author(s):  Yun-fei Feng, Mei-fen Yao, Qi Li, Yan Sun, Cheng-jiang Li, Jian-guo Shen

Affiliation(s):  Department of Endocrinology and Metabolism, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China, Department of Emergency, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China

Corresponding email(s):   jgshen@medmail.com.cn

Key Words:  Fulminant type 1 diabetes, Diabetic ketoacidosis, Flu-like symptoms


Yun-fei Feng, Mei-fen Yao, Qi Li, Yan Sun, Cheng-jiang Li, Jian-guo Shen. Fulminant type 1 diabetes in China: a case report and review of the literature[J]. Journal of Zhejiang University Science B, 2010, 11(11): 848-850.

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author="Yun-fei Feng, Mei-fen Yao, Qi Li, Yan Sun, Cheng-jiang Li, Jian-guo Shen",
journal="Journal of Zhejiang University Science B",
volume="11",
number="11",
pages="848-850",
year="2010",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1000080"
}

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%T Fulminant type 1 diabetes in China: a case report and review of the literature
%A Yun-fei Feng
%A Mei-fen Yao
%A Qi Li
%A Yan Sun
%A Cheng-jiang Li
%A Jian-guo Shen
%J Journal of Zhejiang University SCIENCE B
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%N 11
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1000080

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T1 - Fulminant type 1 diabetes in China: a case report and review of the literature
A1 - Yun-fei Feng
A1 - Mei-fen Yao
A1 - Qi Li
A1 - Yan Sun
A1 - Cheng-jiang Li
A1 - Jian-guo Shen
J0 - Journal of Zhejiang University Science B
VL - 11
IS - 11
SP - 848
EP - 850
%@ 1673-1581
Y1 - 2010
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1000080


Abstract: 
fulminant type 1 diabetes is a recently discovered subtype of idiopathic type 1 diabetes, defined as diabetes with an extremely rapid process of β-cell destruction and progression to hyperglycemia and ketoacidosis. In this report, we present a case of fulminant type 1 diabetes in a 45-year-old Chinese woman, along with a review of the literature. The patient presented with sudden onset of polydipsia and polyuria after flu-like symptoms. Findings on admission included a high blood glucose level and ketoacidosis, but normal HbA1c level. The C-peptide stimulation test showed severe impairment of insulin secretion. Autoantibodies to glutamic acid decarboxylase (GAD) were negative. These results are compatible with the diagnosis of fulminant type 1 diabetes. Human leukocyte antigen-DR7 (HLA-DR7) was available in this case. It is concluded that this rapidly progressing type of diabetes exists, and we propose that HLA-DR7 might be predisposed to fulminant type 1 diabetes in Chinese patients.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

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