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Received: 2007-11-07

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Journal of Zhejiang University SCIENCE B 2008 Vol.9 No.2 P.109-113


Primary leiomyosarcoma of the nipple-areola complex: Report of a case and review of literature

Author(s):  Lai-ching WONG, Po-chi HUANG, Shi-ping LUH, Chiun-sheng HUANG

Affiliation(s):  Department of Pathology, Taichung Hospital, Executive Yuan Department of Health, Taichung 401, Taiwan, China; more

Corresponding email(s):   luh572001@yahoo.com.tw

Key Words:  Breast, Leiomyosarcoma, Mastectomy

Lai-ching WONG, Po-chi HUANG, Shi-ping LUH, Chiun-sheng HUANG. Primary leiomyosarcoma of the nipple-areola complex: Report of a case and review of literature[J]. Journal of Zhejiang University Science B, 2008, 9(2): 109-113.

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author="Lai-ching WONG, Po-chi HUANG, Shi-ping LUH, Chiun-sheng HUANG",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Primary leiomyosarcoma of the nipple-areola complex: Report of a case and review of literature
%A Lai-ching WONG
%A Po-chi HUANG
%A Shi-ping LUH
%A Chiun-sheng HUANG
%J Journal of Zhejiang University SCIENCE B
%V 9
%N 2
%P 109-113
%@ 1673-1581
%D 2008
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0720246

T1 - Primary leiomyosarcoma of the nipple-areola complex: Report of a case and review of literature
A1 - Lai-ching WONG
A1 - Po-chi HUANG
A1 - Shi-ping LUH
A1 - Chiun-sheng HUANG
J0 - Journal of Zhejiang University Science B
VL - 9
IS - 2
SP - 109
EP - 113
%@ 1673-1581
Y1 - 2008
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0720246

Primary leiomyosarcoma of the nipple-areola complex is extremely rare. Less than ten such cases have been reported in English literature so far. Herein we describe a 52-year-old female presenting with a 1.5 cm×1.1 cm×0.7 cm nodular lesion over her left nipple, and leiomyosarcoma was proved by pathological examination of the excised specimen. Positron emitted tomogram (PET) revealed no abnormal signal other than the primary site. Microscopically, this poorly circumscribed tumor was composed of interlacing bundles of smooth muscle cells with bizarre and pleomorphic nuclei, as well as prominent nucleoli. Its mitotic count was up to 7 mitoses per 10 high power fields (HPF). Immunohistochemical study of tumor cells revealed positive stain for α-smooth muscle actin and vimentin; and negative for cytokeratin, CD34 and S-100. Left simple mastectomy was undertaken and no residual mass lesion was noted on the resected specimen. Related literatures about the diagnosis and treatment for breast leiomyosarcoma will be presented here.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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