Full Text:   <3173>

Summary:  <1812>

CLC number: R446.69

On-line Access: 2013-03-06

Received: 2012-07-03

Revision Accepted: 2012-09-27

Crosschecked: 2013-02-02

Cited: 8

Clicked: 5287

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
1. Reference List
Open peer comments

Journal of Zhejiang University SCIENCE B 2013 Vol.14 No.3 P.240-246

http://doi.org/10.1631/jzus.B1200185


Prevalence of sensitization to weed pollens of Humulus scandens, Artemisia vulgaris, and Ambrosia artemisiifolia in northern China


Author(s):  Guo-dong Hao, Yi-wu Zheng, Birgitte Gjesing, Xing-ai Kong, Jing-yuan Wang, Zhi-jing Song, Xu-xin Lai, Nan-shan Zhong, Michael D. Spangfort

Affiliation(s):  Department of Allergy, Tangshan Gongren Hospital, Tangshan 063000, China; more

Corresponding email(s):   Yiwu.Zheng@alk.net

Key Words:  Humulus scandens, Artemisia vulgaris, Ambrosia artemisiifolia, Intradermal test, Specific IgE, Sensitization


Guo-dong Hao, Yi-wu Zheng, Birgitte Gjesing, Xing-ai Kong, Jing-yuan Wang, Zhi-jing Song, Xu-xin Lai, Nan-shan Zhong, Michael D. Spangfort. Prevalence of sensitization to weed pollens of Humulus scandens, Artemisia vulgaris, and Ambrosia artemisiifolia in northern China[J]. Journal of Zhejiang University Science B, 2013, 14(3): 240-246.

@article{title="Prevalence of sensitization to weed pollens of Humulus scandens, Artemisia vulgaris, and Ambrosia artemisiifolia in northern China",
author="Guo-dong Hao, Yi-wu Zheng, Birgitte Gjesing, Xing-ai Kong, Jing-yuan Wang, Zhi-jing Song, Xu-xin Lai, Nan-shan Zhong, Michael D. Spangfort",
journal="Journal of Zhejiang University Science B",
volume="14",
number="3",
pages="240-246",
year="2013",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1200185"
}

%0 Journal Article
%T Prevalence of sensitization to weed pollens of Humulus scandens, Artemisia vulgaris, and Ambrosia artemisiifolia in northern China
%A Guo-dong Hao
%A Yi-wu Zheng
%A Birgitte Gjesing
%A Xing-ai Kong
%A Jing-yuan Wang
%A Zhi-jing Song
%A Xu-xin Lai
%A Nan-shan Zhong
%A Michael D. Spangfort
%J Journal of Zhejiang University SCIENCE B
%V 14
%N 3
%P 240-246
%@ 1673-1581
%D 2013
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1200185

TY - JOUR
T1 - Prevalence of sensitization to weed pollens of Humulus scandens, Artemisia vulgaris, and Ambrosia artemisiifolia in northern China
A1 - Guo-dong Hao
A1 - Yi-wu Zheng
A1 - Birgitte Gjesing
A1 - Xing-ai Kong
A1 - Jing-yuan Wang
A1 - Zhi-jing Song
A1 - Xu-xin Lai
A1 - Nan-shan Zhong
A1 - Michael D. Spangfort
J0 - Journal of Zhejiang University Science B
VL - 14
IS - 3
SP - 240
EP - 246
%@ 1673-1581
Y1 - 2013
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1200185


Abstract: 
Objective: Weed pollens are common sources of allergens worldwide. The prevalence of weed pollen sensitization is not yet fully known in China. The purpose of this study was to investigate the prevalence of sensitization to weed allergens from Artemisia, Ambrosia, and Humulus in northern China. Methods: A total of 1144 subjects (aged from 5 to 68 years) visiting our clinic from June to October 2011 underwent intradermal testing using a panel of 25 allergen sources. Subjects with positive skin responses to any pollen were further tested for their serum concentrations of IgE antibodies against Artemisia vulgaris, Ambrosia artemisiifolia, and Humulus scandens, and against the purified allergens, Art v 1 and Amb a 1. Results: Of 1144 subjects, 170 had positive intradermal reactions to pollen and 144 donated serum for IgE testing. The prevalence of positive intradermal responses to pollens of Artemisia sieversiana, Artemisia annua, A. artemisiifolia, and H. scandens was 11.0%, 10.2%, 3.7%, and 6.6%, respectively. Among the intradermal positive subjects, the prevalence of specific IgE antigens to A. vulgaris was 58.3%, to A. artemisiifolia 14.7%, and to H. scandens 41.0%. The prevalence of specific IgE antigens to the allergen Art v 1 was 46.9%, and to Amb a 1 was 11.2%. The correlation between the presence of IgE antibodies specific to A. vulgaris and to the Art v 1 antigen was very high. Subjects with A. artemisiifolia specific IgE also had A. vulgaris specific IgE, but with relatively high levels of A. vulgaris IgE antibodies. There were no correlations between the presence of IgE antibodies to H. scandens and A. vulgaris or to H. scandens and A. artemisiifolia. Conclusions: The intradermal prevalence of weed pollen sensitization among allergic subjects in northern China is about 13.5%. Correlations of specific IgE antibodies suggest that pollen allergens from Artemisia and Humulus are independent sources for primary sensitization.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]Asero, S., Wopfner, N., Gruber, P., Gadermaier, G., Ferreira, F., 2006. Artemisia and Ambrosia hypersensitivity: co-sensitization or co-recognition. Clin. Exp. Allergy, 36(5):658-665.

[2]Brandes, D., Nitzsche, J., 2006. Biology, introduction, dispersal, and distribution of common ragweed (Ambrosia artemisiifolia L.) with special regard to Germany. Nachrichtenbl. Deut. Pflanzenschutzd, 58(11):286-291.

[3]Gadermaier, G., Wopfner, N., Wallner, M., Egger, M., Didierlaurent, A., Regl, G., Aberger, F., Lang, R., Ferreira, F., Hawranek, T., 2008. Array-based profiling of ragweed and mugwort pollen allergens. Allergy, 63(11):1543-1549.

[4]Han, D., Lai, X., Gjesing, B., Zhong, N.S., Zhang, L., Spangfort, M., 2011. The specific IgE reactivity pattern of weed pollen-induced allergic rhinitis patients. Acta Ota-Laryngol., 131(5):533-538.

[5]Himly, M., Jahn-Schmid, B., Dedic, A., Kelemen, P., Wopfner, N., Altmann, F., van Ree, R., Briza, P., Richter, K., Ebner, C., et al., 2003. Art v 1, the major allergen of mugwort pollen, is a modular glycoprotein with a defensin-like and a hydroyproline-rich domain. FASEB J., 17(1):106-108.

[6]Jimeno, L., Duffort, O., Serrano, C., Barber, D., Polo, F., 2004. Monoclonal antibody-based ELISA to quantify the major allergen of Artemisia vulgaris pollen, Art v 1. Allergy, 59(9):995-1001.

[7]Kang, B.C., Johnson, J., Veres-Thorner, C., 1993. Atopic profile of inner-city asthma with a comparative analysis on the cockroach-sensitive and ragweed-sensitive subgroups. J. Allergy Clin. Immunol., 92(6):802-811.

[8]Katial, R.K., Lin, F.L., Stafford, W.W., Ledoux, R.A., Westley, C.R., Weber, R.W., 1997. Mugwort and sage (Artemisia) pollen cross-reactivity: ELISA inhibition and immunoblot evaluation. Ann. Allergy Asthma Immunol., 79(4):340-346.

[9]Krämer, U., Link, E., Behrendt, H., 2001. Geographic and time trends of pollen count due to beeches, grass and mugwort (Artemisia) in Germany. Pneumologie, 55(5):229-230 (in German).

[10]Li, J., Sun, B., Huang, Y., Lin, X., Zhao, D., Tan, G., Wu, J., Zhao, H., Cao, L., Zhong, N., Chinese Alliance of Research on Respiratory Allergic Disease (CARRAD), 2009. A multicenter study assessing the prevalence of sensitizations in patients with asthma and/or rhinitis in China. Allergy, 64(7):1083-1092.

[11]Li, J., Huang, Y., Lin, X.P., Zhao, D., Tan, G., Wu, J., Zhao, C., Zhao, J., Spangfort, M.D., Zhong, N., China Alliance of Research on Respiratory Allergic Disease (CARRAD), 2011. Influence of degree of specific allergic sensitivity on severity of rhinitis and asthma in Chinese allergic patients. Respir. Res., 12(1):95-103.

[12]Movérare, R., Larsson, H., Carlsson, R., Holmquist, L., 2011. Mugwort-sensitized individuals from North Europe, South Europe and North America show different IgE reactivity patterns. Int. Arch. Allergy Immunol., 154(2):164-172.

[13]Oberhuber, C., Ma, Y., Wopfner, N., Gadermaier, G., Dedic, A., Niggemann, B., Maderegger, B., Gruber, P., Ferreira, F., Scheiner, O., et al., 2008. Prevalence of IgE-binding to Art v 1, Art v 4 and Amb a 1 in mugwort-allergic patients. Int. Arch. Allergy Immunol., 145(2):94-101.

[14]Park, H.S., Jung, K.S., Jee, S.Y., Hong, S.H., Kim, H.Y., Nahm, D.H., 2001. Are there any links between Hop Japanese pollen and other weed pollens or food allergens on skin prick tests? Allergy Asthma Proc., 22(1):43-46.

[15]Park, J.W., Ko, S.K., Kim, C.W., Jeoung, B.J., Hong, C.S., 1999. Identification and characterization of the major allergen of the Humulus japonicus pollen. Clin. Exp. Allergy, 29(8):1080-1086.

[16]Petersen, A.B., Gudmann, P., Milvang-Gronager, P., Mørkeberg, R., Bøgestrand, S., Linneberg, A., Johansen, N., 2004. Performance evaluation of a specific IgE assay developed for the ADVIA Centaur_ immunoassay system. Clin. Biochem., 37(10):882-892.

[17]Qiao, B., Ye, S., 2005. Color Atlas of Air-Borne Pollens and Plants in China. Peking Union Medical College Press, Beijing, China, p.194 (in Chinese).

[18]Schäfer, T., Krämer, U., Dockery, D., Vieluf, D., Behrendt, H., Ring, J., 1999. What makes a child allergic? Analysis of risk factors for allergic sensitisation in preschool children from East and West Germany. Allergy Asthma Proc., 20(1):23-27.

[19]Schmid-Grendelmeier, P., 1998. Pollinosis: clinical aspects and epidemiology. Contribution of the Allergy Clinic 1948-1998. Schweiz Rundsch. Med. Prax., 87:1300-1308 (in German).

[20]Spieksma, F.T., Charpin, H., Nolard, N., Stix, E., 1980. City spore concentrations in the European Economic Community (EEC). IV. Summer weed pollen (Rumex, Plantogo, Chenopodiaceae, Artemisia), 1976 and 1977. Clin. Exp. Allergy, 10:319-329.

[21]Verini, M., Rossi, N., Verrotti, A., Pelaccia, G., Nicodemo, A., Chiarelli, F., 2001. Sensitization to environmental antigens in asthmatic children from a central Italian area. Sci. Total Environ., 270(1-3):63-69.

[22]Yang, Y., Zhao, Y., Wang, C.S., Wang, X.D., Zhang, L., 2011. Prevalence of sensitization to aeroallergens in 10 030 patients with allergic rhinitis. Chin. J. Otolaryngol. Head Neck Surg., 46:914-920 (in Chinese).

[23]Yin, J., Ye, S., Gu, R., 1996. A preliminary investigation into main allergenic pollens during autumnal seasons in Beijing area. Chin. J. Microbiol. Immunol., 16:31-36 (in Chinese).

[24]Zheng, Y.W., Li, J., Lai, X.X., Zhao, D.Y., Liu, X.F., Lin, X.P., Gjesing, B., Palazzo, P., Mari, A., Zhong, N.S., et al., 2011. Allergen micro-array detection of specific IgE reactivity in Chinese allergic patients. Chin. Med. J., 124:4350-4354.

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2024 Journal of Zhejiang University-SCIENCE