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CLC number: R446.69

On-line Access: 2013-03-06

Received: 2012-07-03

Revision Accepted: 2012-09-27

Crosschecked: 2013-02-02

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Journal of Zhejiang University SCIENCE B 2013 Vol.14 No.3 P.240-246

http://doi.org/10.1631/jzus.B1200185


Prevalence of sensitization to weed pollens of Humulus scandens, Artemisia vulgaris, and Ambrosia artemisiifolia in northern China


Author(s):  Guo-dong Hao, Yi-wu Zheng, Birgitte Gjesing, Xing-ai Kong, Jing-yuan Wang, Zhi-jing Song, Xu-xin Lai, Nan-shan Zhong, Michael D. Spangfort

Affiliation(s):  Department of Allergy, Tangshan Gongren Hospital, Tangshan 063000, China; more

Corresponding email(s):   Yiwu.Zheng@alk.net

Key Words:  Humulus scandens, Artemisia vulgaris, Ambrosia artemisiifolia, Intradermal test, Specific IgE, Sensitization


Guo-dong Hao, Yi-wu Zheng, Birgitte Gjesing, Xing-ai Kong, Jing-yuan Wang, Zhi-jing Song, Xu-xin Lai, Nan-shan Zhong, Michael D. Spangfort. Prevalence of sensitization to weed pollens of Humulus scandens, Artemisia vulgaris, and Ambrosia artemisiifolia in northern China[J]. Journal of Zhejiang University Science B, 2013, 14(3): 240-246.

@article{title="Prevalence of sensitization to weed pollens of Humulus scandens, Artemisia vulgaris, and Ambrosia artemisiifolia in northern China",
author="Guo-dong Hao, Yi-wu Zheng, Birgitte Gjesing, Xing-ai Kong, Jing-yuan Wang, Zhi-jing Song, Xu-xin Lai, Nan-shan Zhong, Michael D. Spangfort",
journal="Journal of Zhejiang University Science B",
volume="14",
number="3",
pages="240-246",
year="2013",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1200185"
}

%0 Journal Article
%T Prevalence of sensitization to weed pollens of Humulus scandens, Artemisia vulgaris, and Ambrosia artemisiifolia in northern China
%A Guo-dong Hao
%A Yi-wu Zheng
%A Birgitte Gjesing
%A Xing-ai Kong
%A Jing-yuan Wang
%A Zhi-jing Song
%A Xu-xin Lai
%A Nan-shan Zhong
%A Michael D. Spangfort
%J Journal of Zhejiang University SCIENCE B
%V 14
%N 3
%P 240-246
%@ 1673-1581
%D 2013
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1200185

TY - JOUR
T1 - Prevalence of sensitization to weed pollens of Humulus scandens, Artemisia vulgaris, and Ambrosia artemisiifolia in northern China
A1 - Guo-dong Hao
A1 - Yi-wu Zheng
A1 - Birgitte Gjesing
A1 - Xing-ai Kong
A1 - Jing-yuan Wang
A1 - Zhi-jing Song
A1 - Xu-xin Lai
A1 - Nan-shan Zhong
A1 - Michael D. Spangfort
J0 - Journal of Zhejiang University Science B
VL - 14
IS - 3
SP - 240
EP - 246
%@ 1673-1581
Y1 - 2013
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1200185


Abstract: 
Objective: Weed pollens are common sources of allergens worldwide. The prevalence of weed pollen sensitization is not yet fully known in China. The purpose of this study was to investigate the prevalence of sensitization to weed allergens from Artemisia, Ambrosia, and Humulus in northern China. Methods: A total of 1144 subjects (aged from 5 to 68 years) visiting our clinic from June to October 2011 underwent intradermal testing using a panel of 25 allergen sources. Subjects with positive skin responses to any pollen were further tested for their serum concentrations of IgE antibodies against Artemisia vulgaris, Ambrosia artemisiifolia, and Humulus scandens, and against the purified allergens, Art v 1 and Amb a 1. Results: Of 1144 subjects, 170 had positive intradermal reactions to pollen and 144 donated serum for IgE testing. The prevalence of positive intradermal responses to pollens of Artemisia sieversiana, Artemisia annua, A. artemisiifolia, and H. scandens was 11.0%, 10.2%, 3.7%, and 6.6%, respectively. Among the intradermal positive subjects, the prevalence of specific IgE antigens to A. vulgaris was 58.3%, to A. artemisiifolia 14.7%, and to H. scandens 41.0%. The prevalence of specific IgE antigens to the allergen Art v 1 was 46.9%, and to Amb a 1 was 11.2%. The correlation between the presence of IgE antibodies specific to A. vulgaris and to the Art v 1 antigen was very high. Subjects with A. artemisiifolia specific IgE also had A. vulgaris specific IgE, but with relatively high levels of A. vulgaris IgE antibodies. There were no correlations between the presence of IgE antibodies to H. scandens and A. vulgaris or to H. scandens and A. artemisiifolia. Conclusions: The intradermal prevalence of weed pollen sensitization among allergic subjects in northern China is about 13.5%. Correlations of specific IgE antibodies suggest that pollen allergens from Artemisia and Humulus are independent sources for primary sensitization.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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