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CLC number: R91

On-line Access: 2013-11-04

Received: 2013-03-03

Revision Accepted: 2013-05-03

Crosschecked: 2013-10-16

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Journal of Zhejiang University SCIENCE B 2013 Vol.14 No.11 P.1041-1048


An approach to optimize the batch mixing process for improving the quality consistency of the products made from traditional Chinese medicines

Author(s):  Bin-jun Yan, Hai-bin Qu

Affiliation(s):  Pharmaceutical Informatics Institute, Zhejiang University, Hangzhou 310058, China

Corresponding email(s):   quhb@zju.edu.cn

Key Words:  Batch-to-batch quality consistency, Batch mixing, Production efficiency, Traditional Chinese medicine

Bin-jun Yan, Hai-bin Qu. An approach to optimize the batch mixing process for improving the quality consistency of the products made from traditional Chinese medicines[J]. Journal of Zhejiang University Science B, 2013, 14(11): 1041-1048.

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author="Bin-jun Yan, Hai-bin Qu",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T An approach to optimize the batch mixing process for improving the quality consistency of the products made from traditional Chinese medicines
%A Bin-jun Yan
%A Hai-bin Qu
%J Journal of Zhejiang University SCIENCE B
%V 14
%N 11
%P 1041-1048
%@ 1673-1581
%D 2013
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1300059

T1 - An approach to optimize the batch mixing process for improving the quality consistency of the products made from traditional Chinese medicines
A1 - Bin-jun Yan
A1 - Hai-bin Qu
J0 - Journal of Zhejiang University Science B
VL - 14
IS - 11
SP - 1041
EP - 1048
%@ 1673-1581
Y1 - 2013
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1300059

The efficacy of traditional Chinese medicine (TCM) is based on the combined effects of its constituents. Variation in chemical composition between batches of TCM has always been the deterring factor in achieving consistency in efficacy. The batch mixing process can significantly reduce the batch-to-batch quality variation in TCM extracts by mixing them in a well-designed proportion. However, reducing the quality variation without sacrificing too much of the production efficiency is one of the challenges. Accordingly, an innovative and practical batch mixing method aimed at providing acceptable efficiency for industrial production of TCM products is proposed in this work, which uses a minimum number of batches of extracts to meet the content limits. The important factors affecting the utilization ratio of the extracts (URE) were studied by simulations. The results have shown that URE was affected by the correlation between the contents of constituents, and URE decreased with the increase in the number of targets and the relative standard deviations of the contents. URE could be increased by increasing the number of storage tanks. The results have provided a reference for designing the batch mixing process. The proposed method has possible application value in reducing the quality variation in TCM and providing acceptable production efficiency simultaneously.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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