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CLC number: R737.9

On-line Access: 2024-08-27

Received: 2023-10-17

Revision Accepted: 2024-05-08

Crosschecked: 2014-12-19

Cited: 6

Clicked: 9161

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Chen-fang DONG

http://orcid.org/0000-0003-1123-6732

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Journal of Zhejiang University SCIENCE B 2015 Vol.16 No.1 P.10-17

http://doi.org/10.1631/jzus.B1400172


Epigenetic and metabolic regulation of breast cancer stem cells


Author(s):  Hui-xin Liu, Xiao-li Li, Chen-fang Dong

Affiliation(s):  Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou 310058, China

Corresponding email(s):   chenfangdong@zju.edu.cn

Key Words:  Cancer stem cells (CSCs), Epithelial mesenchymal transition (EMT), Epigenetic modification, Metabolic reprogramming, Breast cancer


Hui-xin Liu, Xiao-li Li, Chen-fang Dong. Epigenetic and metabolic regulation of breast cancer stem cells[J]. Journal of Zhejiang University Science B, 2015, 16(1): 10-17.

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doi="10.1631/jzus.B1400172"
}

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DOI - 10.1631/jzus.B1400172


Abstract: 
breast cancer has a relatively high mortality rate in women due to recurrence and metastasis. Increasing evidence has identified a rare population of cells with stem cell-like properties in breast cancer. These cells, termed cancer stem cells (CSCs), which have the capacity for self-renewal and differentiation, contribute significantly to tumor progression, recurrence, drug resistance and metastasis. Clarifying the mechanisms regulating breast CSCs has important implications for our understanding of breast cancer progression and therapeutics. A strong connection has been found between breast CSCs and epithelial mesenchymal transition (EMT). In addition, recent studies suggest that the maintenance of the breast CSC phenotype is associated with epigenetic and metabolic regulation. In this review, we focus on recent discoveries about the connection between EMT and CSC, and advances made in understanding the roles and mechanisms of epigenetic and metabolic reprogramming in controlling breast CSC properties.

This is a concise and well written review. The authors have reviewed the most recent developments in the field of breast cancer and their own work.

表观遗传修饰和代谢重编程对乳腺癌干细胞的调控

概要:乳腺癌已居我国女性恶性肿瘤死亡率首位。近来研究表明,乳腺肿瘤组织内有少量具有自我更新和分化潜能的肿瘤干细胞,这些肿瘤干细胞在乳腺癌发生、发展、转移及复发过程中起关键作用。深入研究乳腺癌干细胞的调控机制对乳腺癌的预防和治疗具有十分重要意义。本文综合近期的研究成果,概括了表观遗传修饰和代谢重编程对上皮间质转化及乳腺癌干细胞的调控机制,且系统地分析与总结了表观遗传修饰、代谢重编程、上皮间质转化和乳腺癌干细胞之间的相互关系。

关键词:肿瘤干细胞;上皮间质转化;表观遗传修饰;代谢重编程;乳腺癌

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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