Full Text:   <16889>

Summary:  <2503>

CLC number: R737.9

On-line Access: 2015-01-05

Received: 2014-06-25

Revision Accepted: 2014-09-30

Crosschecked: 2014-12-19

Cited: 6

Clicked: 8492

Citations:  Bibtex RefMan EndNote GB/T7714


Chen-fang DONG


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Journal of Zhejiang University SCIENCE B 2015 Vol.16 No.1 P.10-17


Epigenetic and metabolic regulation of breast cancer stem cells

Author(s):  Hui-xin Liu, Xiao-li Li, Chen-fang Dong

Affiliation(s):  Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou 310058, China

Corresponding email(s):   chenfangdong@zju.edu.cn

Key Words:  Cancer stem cells (CSCs), Epithelial mesenchymal transition (EMT), Epigenetic modification, Metabolic reprogramming, Breast cancer

Hui-xin Liu, Xiao-li Li, Chen-fang Dong. Epigenetic and metabolic regulation of breast cancer stem cells[J]. Journal of Zhejiang University Science B, 2015, 16(1): 10-17.

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author="Hui-xin Liu, Xiao-li Li, Chen-fang Dong",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%T Epigenetic and metabolic regulation of breast cancer stem cells
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T1 - Epigenetic and metabolic regulation of breast cancer stem cells
A1 - Hui-xin Liu
A1 - Xiao-li Li
A1 - Chen-fang Dong
J0 - Journal of Zhejiang University Science B
VL - 16
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SP - 10
EP - 17
%@ 1673-1581
Y1 - 2015
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1400172

breast cancer has a relatively high mortality rate in women due to recurrence and metastasis. Increasing evidence has identified a rare population of cells with stem cell-like properties in breast cancer. These cells, termed cancer stem cells (CSCs), which have the capacity for self-renewal and differentiation, contribute significantly to tumor progression, recurrence, drug resistance and metastasis. Clarifying the mechanisms regulating breast CSCs has important implications for our understanding of breast cancer progression and therapeutics. A strong connection has been found between breast CSCs and epithelial mesenchymal transition (EMT). In addition, recent studies suggest that the maintenance of the breast CSC phenotype is associated with epigenetic and metabolic regulation. In this review, we focus on recent discoveries about the connection between EMT and CSC, and advances made in understanding the roles and mechanisms of epigenetic and metabolic reprogramming in controlling breast CSC properties.

This is a concise and well written review. The authors have reviewed the most recent developments in the field of breast cancer and their own work.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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