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Guiwen YANG


Guorong LI


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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.8 P.642-654


Translationally controlled tumor protein: the mediator promoting cancer invasion and migration and its potential clinical prospects

Author(s):  Junying GAO, Yan MA, Guiwen YANG, Guorong LI

Affiliation(s):  Shandong Provincial Key Laboratory of Animal Resistant, School of Life Sciences, Shandong Normal University, Jinan 250014, China

Corresponding email(s):   yanggw@sdnu.edu.cn, grli@sdnu.edu.cn

Key Words:  Translationally controlled tumor protein (TCTP), Invasion, Migration, Cancer, Clinical drugs

Junying GAO, Yan MA, Guiwen YANG, Guorong LI. Translationally controlled tumor protein: the mediator promoting cancer invasion and migration and its potential clinical prospects[J]. Journal of Zhejiang University Science B, 2022, 23(8): 642-654.

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author="Junying GAO, Yan MA, Guiwen YANG, Guorong LI",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%T Translationally controlled tumor protein: the mediator promoting cancer invasion and migration and its potential clinical prospects
%A Junying GAO
%A Yan MA
%A Guiwen YANG
%A Guorong LI
%J Journal of Zhejiang University SCIENCE B
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%P 642-654
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2100910

T1 - Translationally controlled tumor protein: the mediator promoting cancer invasion and migration and its potential clinical prospects
A1 - Junying GAO
A1 - Yan MA
A1 - Guiwen YANG
A1 - Guorong LI
J0 - Journal of Zhejiang University Science B
VL - 23
IS - 8
SP - 642
EP - 654
%@ 1673-1581
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2100910

translationally controlled tumor protein (TCTP) is a highly conserved multifunctional protein localized in the cytoplasm and nucleus of eukaryotic cells. It is secreted through exosomes and its degradation is associated with the ubiquitin-proteasome system (UPS), heat shock protein 27 (Hsp27), and chaperone-mediated autophagy (CMA). Its structure contains three α‍-helices and elevenβ‍-strands, and features a helical hairpin as its hallmark. TCTP shows a remarkable similarity to the methionine-R-sulfoxide reductase B (MsrB) and mammalian suppressor of Sec4 (Mss4/Dss4) protein families, which exerts guanine nucleotide exchange factor (GEF) activity on small guanosine triphosphatase (GTPase) proteins, suggesting that some functions of TCTP may at least depend on its GEF action. Indeed, TCTP exerts GEF activity on Ras homolog enriched in brain (Rheb) to boost the growth and proliferation of Drosophila cells. TCTP also enhances the expression of cell division control protein 42 homolog (Cdc42) to promote cancer cell invasion and migration. Moreover, TCTP regulates cytoskeleton organization by interacting with actin microfilament (MF) and microtubule (MT) proteins and inducing the epithelial-mesenchymal transition (EMT) process. In essence, TCTP promotes cancer cell movement. It is usually highly expressed in cancerous tissues and thus reduces patient survival; meanwhile, drugs can target TCTP to reduce this effect. In this review, we summarize the mechanisms of TCTP in promoting cancer invasion and migration, and describe the current inhibitory strategy to target TCTP in cancerous diseases.




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