Full Text:   <2036>

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CLC number: R589.2

On-line Access: 2015-05-04

Received: 2014-06-30

Revision Accepted: 2015-01-27

Crosschecked: 2015-04-09

Cited: 3

Clicked: 3250

Citations:  Bibtex RefMan EndNote GB/T7714


Ming Zhong


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Journal of Zhejiang University SCIENCE B 2015 Vol.16 No.5 P.380-387


Pitavastatin calcium improves endothelial function and delays the progress of atherosclerosis in patients with hypercholesterolemia

Author(s):  Jing Zhao, Hui-min Yan, Ya Li, Jia Wang, Lu Han, Zhi-hao Wang, Meng-xiong Tang, Wei Zhang, Yun Zhang, Ming Zhong

Affiliation(s):  Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital of Shandong University, Ji’nan 250012, China; more

Corresponding email(s):   zhongmingzm@gmail.com

Key Words:  Flow-mediated vasodilatation (FMD), Hypercholesterolemia (HC), Carotid intima-media thickness (IMT), Pitavastatin calcium

Jing Zhao, Hui-min Yan, Ya Li, Jia Wang, Lu Han, Zhi-hao Wang, Meng-xiong Tang, Wei Zhang, Yun Zhang, Ming Zhong. Pitavastatin calcium improves endothelial function and delays the progress of atherosclerosis in patients with hypercholesterolemia[J]. Journal of Zhejiang University Science B, 2015, 16(5): 380-387.

@article{title="Pitavastatin calcium improves endothelial function and delays the progress of atherosclerosis in patients with hypercholesterolemia",
author="Jing Zhao, Hui-min Yan, Ya Li, Jia Wang, Lu Han, Zhi-hao Wang, Meng-xiong Tang, Wei Zhang, Yun Zhang, Ming Zhong",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Pitavastatin calcium improves endothelial function and delays the progress of atherosclerosis in patients with hypercholesterolemia
%A Jing Zhao
%A Hui-min Yan
%A Ya Li
%A Jia Wang
%A Lu Han
%A Zhi-hao Wang
%A Meng-xiong Tang
%A Wei Zhang
%A Yun Zhang
%A Ming Zhong
%J Journal of Zhejiang University SCIENCE B
%V 16
%N 5
%P 380-387
%@ 1673-1581
%D 2015
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1400181

T1 - Pitavastatin calcium improves endothelial function and delays the progress of atherosclerosis in patients with hypercholesterolemia
A1 - Jing Zhao
A1 - Hui-min Yan
A1 - Ya Li
A1 - Jia Wang
A1 - Lu Han
A1 - Zhi-hao Wang
A1 - Meng-xiong Tang
A1 - Wei Zhang
A1 - Yun Zhang
A1 - Ming Zhong
J0 - Journal of Zhejiang University Science B
VL - 16
IS - 5
SP - 380
EP - 387
%@ 1673-1581
Y1 - 2015
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1400181

Background: Statins have proven efficacy in inhibiting the onset and progress of atherosclerosis. The effectiveness of pitavastatin in reversing carotid atherosclerosis associated with hypercholesterolemia (HC) is unknown. Objectives: To explore the simultaneous effects of pitavastatin calcium on brachial arterial flow-mediated vasodilatation (FMD), carotid intima-media thickness (IMT), and arterial stiffness (β), three surrogate markers of atherosclerosis were studied in HC patients. Methods: A randomized, double-blind trial was performed with 40 HC subjects who fulfilled the inclusion/exclusion criteria. Patients were given pitavastatin calcium 1 mg/d (Group 1) or 2 mg/d (Group 2) for 8 weeks. There were 20 patients in each group, and 30 gender- and age-matched healthy subjects as controls were recruited. FMD of the brachial artery, carotid IMT, and arterial stiffness indicated by β were measured at baseline and at 8 weeks after starting pitavastatin calcium therapy using ultrasound techniques. Biochemical tests were also made on all subjects. Results: At baseline, higher total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), reduced FMD, and increased β and IMT were observed in HC patients (P<0.001 for all) compared with controls. After 8 weeks, TC was decreased by 20.59%/27.56% and LDL-C 30.92%/35.64%, respectively, in comparison to baseline groups; the HC groups had reduced β and improved endothelial function over the 8-week follow-up (P<0.05–0.001); nonetheless, no significant alterations of IMT were found (P>0.05). Significant negative interactions between TC/LDL and FMD (P<0.05–0.001), positive interactions between TC and IMT (P=0.003) and between TC/LDL and β (P<0.001–0.000) were found. Conclusions: Treatment with pitavastatin calcium exerted favorable effects on endothelial function and arterial stiffness. It also improved carotid atherosclerosis in patients with HC.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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