CLC number: R543.1
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2015-04-09
Cited: 6
Clicked: 4549
Zhen-kun Yang, Chen Ying, Hong-yan Zhao, Yue-hua Fang, Ying Chen, Wei-feng Shen. Mineral metabolism disturbances are associated with the presence and severity of calcific aortic valve disease[J]. Journal of Zhejiang University Science B, 2015, 16(5): 362-369.
@article{title="Mineral metabolism disturbances are associated with the presence and severity of calcific aortic valve disease",
author="Zhen-kun Yang, Chen Ying, Hong-yan Zhao, Yue-hua Fang, Ying Chen, Wei-feng Shen",
journal="Journal of Zhejiang University Science B",
volume="16",
number="5",
pages="362-369",
year="2015",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1400292"
}
%0 Journal Article
%T Mineral metabolism disturbances are associated with the presence and severity of calcific aortic valve disease
%A Zhen-kun Yang
%A Chen Ying
%A Hong-yan Zhao
%A Yue-hua Fang
%A Ying Chen
%A Wei-feng Shen
%J Journal of Zhejiang University SCIENCE B
%V 16
%N 5
%P 362-369
%@ 1673-1581
%D 2015
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1400292
TY - JOUR
T1 - Mineral metabolism disturbances are associated with the presence and severity of calcific aortic valve disease
A1 - Zhen-kun Yang
A1 - Chen Ying
A1 - Hong-yan Zhao
A1 - Yue-hua Fang
A1 - Ying Chen
A1 - Wei-feng Shen
J0 - Journal of Zhejiang University Science B
VL - 16
IS - 5
SP - 362
EP - 369
%@ 1673-1581
Y1 - 2015
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1400292
Abstract: Objective: We investigated whether disturbance of calcium and phosphate metabolism is associated with the presence and severity of calcific aortic valve disease (CAVD) in patients with normal or mildly impaired renal function. Methods: We measured serum levels of calcium, phosphate, alkaline phosphatase (AKP), intact parathyroid hormone (iPTH), 25-hydroxyvitamin D (25-OHD), and biomarkers of bone turnover in 260 consecutive patients with normal or mildly impaired renal function and aortic valve sclerosis (AVSc) (n=164) or stenosis (AVS) (n=96) and in 164 age- and gender-matched controls. Logistic regression models were used to determine the association of mineral metabolism parameters with the presence and severity of CAVD. Results: Stepwise increases were observed in serum levels of calcium, phosphate, AKP, and iPTH from the control group to patients with AVS, and with reverse changes for 25-OHD levels (all P<0.001). Similarly, osteocalcin, procollagen I N-terminal peptide, and β-isomerized type I collagen C-telopeptide breakdown products were significantly increased stepwise from the control group to patients with AVS (all P<0.001). In patients with AVS, serum levels of iPTH were positively, in contrast 25-OHD levels were negatively, related to trans-aortic peak flow velocity and mean pressure gradient. After adjusting for relevant confounding variables, increased serum levels of calcium, phosphate, AKP, and iPTH and reduced serum levels of 25-OHD were independently associated with the presence and severity of CAVD. Conclusions: This study suggests an association between mineral metabolism disturbance and the presence and severity of CAVD in patients with normal or mildly impaired renal function. Abnormal bone turnover may be a potential mechanism.
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