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Hai-tao Zhu


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Journal of Zhejiang University SCIENCE B 2015 Vol.16 No.5 P.329-343


Treatment of diabetes with encapsulated pig islets: an update on current developments

Author(s):  Hai-tao Zhu, Lu Lu, Xing-yu Liu, Liang Yu, Yi Lyu, Bo Wang

Affiliation(s):  Heart Center, Northwest Women’s and Children’s Hospital, Xi’an 710061, China; more

Corresponding email(s):   zht0915@163.com, bobwang75@yeah.net

Key Words:  Encapsulation, Pig, Islet, Xenotransplantation, Diabetes mellitus

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Hai-tao Zhu, Lu Lu, Xing-yu Liu, Liang Yu, Yi Lyu, Bo Wang. Treatment of diabetes with encapsulated pig islets: an update on current developments[J]. Journal of Zhejiang University Science B, 2015, 16(5): 329-343.

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A1 - Hai-tao Zhu
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A1 - Xing-yu Liu
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1400310

The potential use of allogeneic islet transplantation in curing type 1 diabetes mellitus has been adequately demonstrated, but its large-scale application is limited by the short supply of donor islets and the need for sustained and heavy immunosuppressive therapy. encapsulation of pig islets was therefore suggested with a view to providing a possible alternative source of islet grafts and avoiding chronic immunosuppression and associated adverse or toxic effects. Nevertheless, several vital elements should be taken into account before this therapy becomes a clinical reality, including cell sources, encapsulation approaches, and implantation sites. This paper provides a comprehensive review of xenotransplantation of encapsulated pig islets for the treatment of type 1 diabetes mellitus, including current research findings and suggestions for future studies.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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