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CLC number: R733.71

On-line Access: 2020-09-07

Received: 2019-12-30

Revision Accepted: 2020-06-17

Crosschecked: 2020-08-17

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Citations:  Bibtex RefMan EndNote GB/T7714


Jie Jin


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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.9 P.740-744


Characteristics of chemotherapy-induced diabetes mellitus in acute lymphoblastic leukemia patients

Author(s):  Shan-shan Suo, Chen-ying Li, Yi Zhang, Jing-han Wang, Yin-jun Lou, Wen-juan Yu, Jie Jin

Affiliation(s):  Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; more

Corresponding email(s):   jiej0503@zju.edu.cn

Key Words:  Acute lymphoblastic leukemia, Diabetes mellitus, Clinical characteristics

Shan-shan Suo, Chen-ying Li, Yi Zhang, Jing-han Wang, Yin-jun Lou, Wen-juan Yu, Jie Jin. Characteristics of chemotherapy-induced diabetes mellitus in acute lymphoblastic leukemia patients[J]. Journal of Zhejiang University Science B, 2020, 21(9): 740-744.

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T1 - Characteristics of chemotherapy-induced diabetes mellitus in acute lymphoblastic leukemia patients
A1 - Shan-shan Suo
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A1 - Yi Zhang
A1 - Jing-han Wang
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A1 - Wen-juan Yu
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Acute lymphocytic leukemia (ALL) is one of the most common malignancies, especially in young people. Combination chemotherapy for ALL typically includes corticosteroids (Kantarjian et al., 2000). Hyperglycemia is a well-recognized complication of corticosteroids, and chemotherapy-induced diabetes (CID) is not uncommon (27.5%–37.0%) during the treatment of ALL (Hsu et al., 2002; Weiser et al., 2004; Alves et al., 2007). Besides the effect of corticosteroids, potential factors triggering hyperglycemia in ALL also include direct infiltration of the pancreas by leukemia cells and β cell dysfunction induced by chemotherapeutic agents such as L-asparagine (Mohn et al., 2004).




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