Full Text:   <3623>

Summary:  <2272>

CLC number: R542.5

On-line Access: 2015-03-05

Received: 2015-01-21

Revision Accepted: 2015-02-23

Crosschecked: 2015-02-26

Cited: 13

Clicked: 6596

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Xian-bao Liu

http://orcid.org/0000-0002-2891-7019

Jian-an Wang

http://orcid.org/0000-0003-0409-8941

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Journal of Zhejiang University SCIENCE B 2015 Vol.16 No.3 P.208-214

http://doi.org/10.1631/jzus.B1500017


Evaluation of the safety and efficacy of transcatheter aortic valve implantation in patients with a severe stenotic bicuspid aortic valve in a Chinese population


Author(s):  Xian-bao Liu, Ju-bo Jiang, Qi-jing Zhou, Zhao-xia Pu, Wei He, Ai-qiang Dong, Yan Feng, Jun Jiang, Yong Sun, Mei-xiang Xiang, Yu-xin He, You-qi Fan, Liang Dong, Jian-an Wang

Affiliation(s):  Cardiovascular Key Lab of Zhejiang Province, Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China; more

Corresponding email(s):   jian_an_wang@yahoo.com

Key Words:  Aortic valve stenosis, Bicuspid aortic valve, Transcatheter aortic valve implantation A comment on this article is available from http://www.jzus.zju.edu.cn//article.php?doi=10.1631/jzus.B1500063


Xian-bao Liu, Ju-bo Jiang, Qi-jing Zhou, Zhao-xia Pu, Wei He, Ai-qiang Dong, Yan Feng, Jun Jiang, Yong Sun, Mei-xiang Xiang, Yu-xin He, You-qi Fan, Liang Dong, Jian-an Wang. Evaluation of the safety and efficacy of transcatheter aortic valve implantation in patients with a severe stenotic bicuspid aortic valve in a Chinese population[J]. Journal of Zhejiang University Science B, 2015, 16(3): 208-214.

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author="Xian-bao Liu, Ju-bo Jiang, Qi-jing Zhou, Zhao-xia Pu, Wei He, Ai-qiang Dong, Yan Feng, Jun Jiang, Yong Sun, Mei-xiang Xiang, Yu-xin He, You-qi Fan, Liang Dong, Jian-an Wang",
journal="Journal of Zhejiang University Science B",
volume="16",
number="3",
pages="208-214",
year="2015",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1500017"
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%T Evaluation of the safety and efficacy of transcatheter aortic valve implantation in patients with a severe stenotic bicuspid aortic valve in a Chinese population
%A Xian-bao Liu
%A Ju-bo Jiang
%A Qi-jing Zhou
%A Zhao-xia Pu
%A Wei He
%A Ai-qiang Dong
%A Yan Feng
%A Jun Jiang
%A Yong Sun
%A Mei-xiang Xiang
%A Yu-xin He
%A You-qi Fan
%A Liang Dong
%A Jian-an Wang
%J Journal of Zhejiang University SCIENCE B
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1500017

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A1 - Xian-bao Liu
A1 - Ju-bo Jiang
A1 - Qi-jing Zhou
A1 - Zhao-xia Pu
A1 - Wei He
A1 - Ai-qiang Dong
A1 - Yan Feng
A1 - Jun Jiang
A1 - Yong Sun
A1 - Mei-xiang Xiang
A1 - Yu-xin He
A1 - You-qi Fan
A1 - Liang Dong
A1 - Jian-an Wang
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DOI - 10.1631/jzus.B1500017


Abstract: 
Objective: The purpose of this study is to evaluate the safety and efficacy of transcatheter aortic valve implantation (TAVI) in patients with a severe stenotic bicuspid aortic valve (BAV) in a Chinese population. While several groups have reported the feasibility, efficacy, and safety of TAVI for patients with a BAV, worldwide experience of the technique is still limited, especially in China. Methods: From March 2013 to November 2014, high surgical risk or inoperable patients with symptomatic severe aortic stenosis (AS) who had undergone TAVI at our institution were selected for inclusion in our study. Results were compared between a BAV group and a tricuspid aortic valve (TAV) group. Results: Forty patients were included in this study, 15 (37.5%) of whom were identified as having a BAV. In the BAV group, the aortic valve area was smaller ((0.47±0.13) vs. (0.59±0.14) cm2), the ascending aortic diameter was larger ((40.4±4.4) vs. (36.4±4.3) mm), and the concomitant aortic regurgitation was lower. No significant differences were found between the groups in the other baseline characteristics. No differences were observed either in the choice of access or valve size. The procedural success achieved in this study was 100%. There were no differences between groups in device success (86.7% vs. 88.0%), 30-d mortality (6.7% vs. 8.0%), or 30-d combined end point (13.3% vs. 12.0%). The incidences of new pacemaker implantation, paravalvular regurgitation and other complications, recovery of left ventricle ejection fraction and heart function were similar in both groups. Conclusions: Patients with a severely stenotic BAV can be treated with TAVI, and their condition after treatment should be similar to that of people with a TAV.

经导管主动脉瓣置入术在中国人群二叶式主动脉瓣重度狭窄中的安全性和有效性评估

中文概要:
目的:评估经导管主动脉瓣置入术在中国人群二叶式主动脉瓣重度狭窄中的安全性和有效性。
创新点:首次在中国人群比较经导管主动脉瓣置入术在二叶式和三叶式主动脉瓣重度狭窄中的安全性和有效性。
方法:选取2013年3月至2014年9月行经导管主动脉瓣置入术的40位主动脉瓣狭窄的患者,分二叶式和三叶式主动脉瓣两组,比较基线水平、手术以及随访1月结果的差别。
结论:经导管主动脉瓣置入术在中国人群中二叶式主动脉瓣重度狭窄中的应用是安全有效的。

关键词:主动脉瓣狭窄;二叶式主动脉瓣;经导管主动脉瓣置入术

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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