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CLC number: R605

On-line Access: 2016-03-07

Received: 2015-12-20

Revision Accepted: 2016-02-13

Crosschecked: 2016-02-19

Cited: 2

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Citations:  Bibtex RefMan EndNote GB/T7714


Chong Lai


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Journal of Zhejiang University SCIENCE B 2016 Vol.17 No.3 P.236-246


Comparison of laparoscopic hepatectomy, percutaneous radiofrequency ablation and open hepatectomy in the treatment of small hepatocellular carcinoma

Author(s):  Chong Lai, Ren-an Jin, Xiao Liang, Xiu-jun Cai

Affiliation(s):  Department of Surgery, Institute of Minimally Invasive Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China; more

Corresponding email(s):   clai8827@zju.edu.cn, caixiujunzju@163.com

Key Words:  Hepatocellular carcinoma, Laparoscopic hepatectomy, Minimally invasive techniques, Open hepatectomy, Percutaneous radiofrequency ablation

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Chong Lai, Ren-an Jin, Xiao Liang, Xiu-jun Cai. Comparison of laparoscopic hepatectomy, percutaneous radiofrequency ablation and open hepatectomy in the treatment of small hepatocellular carcinoma[J]. Journal of Zhejiang University Science B, 2016, 17(3): 236-246.

@article{title="Comparison of laparoscopic hepatectomy, percutaneous radiofrequency ablation and open hepatectomy in the treatment of small hepatocellular carcinoma",
author="Chong Lai, Ren-an Jin, Xiao Liang, Xiu-jun Cai",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Comparison of laparoscopic hepatectomy, percutaneous radiofrequency ablation and open hepatectomy in the treatment of small hepatocellular carcinoma
%A Chong Lai
%A Ren-an Jin
%A Xiao Liang
%A Xiu-jun Cai
%J Journal of Zhejiang University SCIENCE B
%V 17
%N 3
%P 236-246
%@ 1673-1581
%D 2016
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1500322

T1 - Comparison of laparoscopic hepatectomy, percutaneous radiofrequency ablation and open hepatectomy in the treatment of small hepatocellular carcinoma
A1 - Chong Lai
A1 - Ren-an Jin
A1 - Xiao Liang
A1 - Xiu-jun Cai
J0 - Journal of Zhejiang University Science B
VL - 17
IS - 3
SP - 236
EP - 246
%@ 1673-1581
Y1 - 2016
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1500322

Objective: Three mainstream techniques—laparoscopic hepatectomy (LH), percutaneous radiofrequency ablation (pRFA), and open hepatectomy (OH)—were compared in this study, in terms of their efficacies in the treatment of small hepatocellular carcinoma (HCC). Methods: A comparative study was performed within a total of 94 patients diagnosed with small HCC in our hospital from 2005 to 2010, who underwent LH (28), RFA (33), or OH (33). They had either a single tumor lesion of less than or up to three nodules with diameters of less than each. Outcomes were carefully evaluated throughout a 3-year follow-up interval and statistically interpreted. Results: The pRFA group had a significantly lower disease-free survival rate compared with the two surgical groups (P=0.001) and significantly shorter overall survival (P=0.005), while the LH group and the OH group had no difference in survival results. For patients younger than 60 years old, surgical approaches offered a better long-term overall survival prognosis (P=0.008). There were no statistically significant differences among the three groups in overall survival for elderly patients (P=0.104). Conclusions: Among patients with small HCC, LH may provide better curative effects than pRFA without increasing complication rates. pRFA leads to faster recurrence than surgical resections. LH has similar therapeutic effects to OH and causes less trauma. For patients younger than 60 years old, LH may be the best curative treatment. Elderly patients may choose either surgery or pRFA.


方法:选取2005年至2010年间94例符合单个肿瘤直径小于5 cm或不超过3个肿瘤且每个肿瘤直径小于3 cm的小肝癌患者,分至3个治疗组,分别为腹腔镜肝切除组(28例)、经皮射频消融组(33例)和开放肝切除组(33例)。经过3年的跟踪随访,统计比较3组患者的疾病预后及相关指标。


Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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