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CLC number: R741

On-line Access: 2017-07-05

Received: 2016-08-01

Revision Accepted: 2016-10-26

Crosschecked: 2017-06-16

Cited: 1

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Citations:  Bibtex RefMan EndNote GB/T7714


Ling-ling Yao


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Journal of Zhejiang University SCIENCE B 2017 Vol.18 No.7 P.577-585


Factors affecting cerebrospinal fluid opening pressure in patients with spontaneous intracranial hypotension

Author(s):  Ling-ling Yao, Xing-yue Hu

Affiliation(s):  Department of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China

Corresponding email(s):   605175902@qq.com, huxingyue2003@126.com

Key Words:  Spontaneous intracranial hypotension, Low cerebrospinal fluid opening pressure, Body mass index, Magnetic resonance imaging

Ling-ling Yao, Xing-yue Hu. Factors affecting cerebrospinal fluid opening pressure in patients with spontaneous intracranial hypotension[J]. Journal of Zhejiang University Science B, 2017, 18(7): 577-585.

@article{title="Factors affecting cerebrospinal fluid opening pressure in patients with spontaneous intracranial hypotension",
author="Ling-ling Yao, Xing-yue Hu",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Factors affecting cerebrospinal fluid opening pressure in patients with spontaneous intracranial hypotension
%A Ling-ling Yao
%A Xing-yue Hu
%J Journal of Zhejiang University SCIENCE B
%V 18
%N 7
%P 577-585
%@ 1673-1581
%D 2017
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1600343

T1 - Factors affecting cerebrospinal fluid opening pressure in patients with spontaneous intracranial hypotension
A1 - Ling-ling Yao
A1 - Xing-yue Hu
J0 - Journal of Zhejiang University Science B
VL - 18
IS - 7
SP - 577
EP - 585
%@ 1673-1581
Y1 - 2017
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1600343

Objective: spontaneous intracranial hypotension (SIH) is recognized far more commonly than ever before. Though usually characterized by low cerebrospinal fluid (CSF) pressure, some patients with SIH are observed to have normal pressure values. In this study, we aimed to confirm the proportion of patients with normal CSF opening pressure (CSF OP) and explore the factors affecting CSF OP in SIH patients. Methods: We retrospectively reviewed 206 consecutive SIH patients and analyzed their clinical and imaging variables (including demographic data, body mass index (BMI), duration of symptoms, and brain imaging findings). Univariate and multivariate analyses were performed to identify the potential factors affecting CSF OP. Results: In a total of 114 (55.3%) cases the CSF OP was ≤60 mmH2O (1 mmH2O=9.806 65 Pa), in 90 (43.7%) cases it was between 60 and 200 mmH2O, and in 2 (1.0%) cases it was >200 mmH2O. Univariate analysis showed that the duration of symptoms (P<0.001), BMI (P<0.001), and age (P=0.024) were positively correlated with CSF OP. However, multivariate analysis suggested that only the duration of symptoms (P<0.001) and BMI (P<0.001) were strongly correlated with CSF OP. A relatively high R2 of 0.681 was obtained for the multivariate model. Conclusions: Our study indicated that in patients without a low CSF OP, a diagnosis of SIH should not be excluded. BMI and the duration of symptoms can influence CSF OP in SIH patients, and other potential factors need further investigation.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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