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CLC number: R589.2

On-line Access: 2015-05-04

Received: 2014-08-08

Revision Accepted: 2015-03-17

Crosschecked: 2015-04-09

Cited: 2

Clicked: 2942

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Danuta Rość

http://orcid.org/0000-0002-2971-9882

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Journal of Zhejiang University SCIENCE B 2015 Vol.16 No.5 P.404-411

http://doi.org/10.1631/jzus.B1400219


CRP, but not TNF-α or IL-6, decreases after weight loss in patients with morbid obesity exposed to intensive weight reduction and balneological treatment


Author(s):  Danuta Rość, Przemysław Adamczyk, Joanna Boinska, Robert Szafkowski, Irena Ponikowska, Katarzyna Stankowska, Barbara Góralczyk, Barbara Ruszkowska-Ciastek

Affiliation(s):  Department of Pathophysiology, Faculty of Pharmacy, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Bydgoszcz PL 85-094, Poland; more

Corresponding email(s):   drosc@cm.umk.pl

Key Words:  Pro-inflammatory cytokines, Tumor necrosis factor-α, (TNF-α, ), Interleukin-6 (IL-6), Morbid obesity, C-reactive protein (CRP), Homeostasis model assessment-insulin resistance (HOMA-IR)


Danuta Rość, Przemysław Adamczyk, Joanna Boinska, Robert Szafkowski, Irena Ponikowska, Katarzyna Stankowska, Barbara Góralczyk, Barbara Ruszkowska-Ciastek. CRP, but not TNF-α or IL-6, decreases after weight loss in patients with morbid obesity exposed to intensive weight reduction and balneological treatment[J]. Journal of Zhejiang University Science B, 2015, 16(5): 404-411.

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author="Danuta Rość, Przemysław Adamczyk, Joanna Boinska, Robert Szafkowski, Irena Ponikowska, Katarzyna Stankowska, Barbara Góralczyk, Barbara Ruszkowska-Ciastek",
journal="Journal of Zhejiang University Science B",
volume="16",
number="5",
pages="404-411",
year="2015",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1400219"
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%0 Journal Article
%T CRP, but not TNF-α or IL-6, decreases after weight loss in patients with morbid obesity exposed to intensive weight reduction and balneological treatment
%A Danuta Rość
%A Przemysław Adamczyk
%A Joanna Boinska
%A Robert Szafkowski
%A Irena Ponikowska
%A Katarzyna Stankowska
%A Barbara Góralczyk
%A Barbara Ruszkowska-Ciastek
%J Journal of Zhejiang University SCIENCE B
%V 16
%N 5
%P 404-411
%@ 1673-1581
%D 2015
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1400219

TY - JOUR
T1 - CRP, but not TNF-α or IL-6, decreases after weight loss in patients with morbid obesity exposed to intensive weight reduction and balneological treatment
A1 - Danuta Rość
A1 - Przemysław Adamczyk
A1 - Joanna Boinska
A1 - Robert Szafkowski
A1 - Irena Ponikowska
A1 - Katarzyna Stankowska
A1 - Barbara Góralczyk
A1 - Barbara Ruszkowska-Ciastek
J0 - Journal of Zhejiang University Science B
VL - 16
IS - 5
SP - 404
EP - 411
%@ 1673-1581
Y1 - 2015
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1400219


Abstract: 
Objective: The aim of this study was to evaluate the concentrations of C-reactive protein (CRP), tumor necrosis factor-α; (TNF-α;), interleukin-6 (IL-6), and the degree of homeostasis model assessment-insulin resistance (HOMA-IR) in patients with morbid obesity exposed to a three-week low-calorie diet and balneotherapy. Methods: The study included 33 patients (25 females and 8 males; mean age 46 years) with body mass index (BMI) values of >40 kg/m2. Evaluations of CRP, IL-6, TNF-α, lipid profile, HOMA-IR, and fasting glucose were carried out before (baseline data) and three weeks after the treatment. The control group consisted of 20 healthy volunteers (15 females and 5 males) with a mean age of 39 years and BMI values of ≤24.9 kg/m2. Results: In the blood of patients with morbid obesity we found significantly elevated levels of CRP, TNF-α, triglycerides, HOMA-IR and fasting glucose, but a decreased level of high density lipoprotein (HDL)-cholesterol, compared with the healthy individuals. The treatment resulted in about a 9.4% reduction in body weight from 122.5 to 111.0 kg and a significant decrease in the concentration of CRP, but no change in TNF-α or IL-6. HOMA-IR was significantly reduced. Conclusions: The decrease in CRP level without changes in TNF-α or IL-6 concentrations after the low-calorie diet and balneological treatment, suggests that an essential amount of adipose tissue must be removed before proper adipocyte function is restored. The decrease in HOMA-IR indicates an improvement in insulin sensitivity, which is beneficial in obese patients.

病态肥胖患者在接受治疗体重减少后C反应蛋白、肿瘤坏死因子α和白细胞介素-6的水平变化

目的:评估病态肥胖患者在低热量饮食和浸浴治疗前后,C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素-6(IL-6)以及胰岛素抵抗指数(HOMA-IR)的水平变化。
创新点:研究炎症反应对病态肥胖的影响。
方法:本研究包括33个病例和20个正常对照,对治疗前后的CRP、IL-6、TNF-α、血脂谱、HOMA-IR以及空腹血糖水平进行评估。
结论:与对照组相比,低热量饮食和浸浴治疗后,病态肥胖患者的CRP水平显著降低,而TNF-α和IL-6的水平却没有显著变化,这表明脂肪细胞的正常功能恢复之前必须先去除一定量的脂肪组织。HOMA-IR水平的降低说明对胰岛素的敏感性有所提高,这有利于肥胖患者的治疗。

关键词:促炎性细胞因子;肿瘤坏死因子α;白细胞介素-6;C反应蛋白;病态肥胖症;胰岛素抵抗指数

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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