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CLC number: R654.2

On-line Access: 2018-05-05

Received: 2017-09-24

Revision Accepted: 2018-01-25

Crosschecked: 2018-04-18

Cited: 0

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Citations:  Bibtex RefMan EndNote GB/T7714


Qun Luo


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Journal of Zhejiang University SCIENCE B 2018 Vol.19 No.5 P.342-348


Early diagnosis of acute kidney injury in aged patients undergoing percutaneous coronary intervention

Author(s):  Hong-Hua Ye, Gen Shen, Qun Luo, Fang-Fang Zhou, Xiao-Ling Xie, Chun-Yan Wang, Li-Na Han

Affiliation(s):  Department of Cardiology, Ningbo No. 2 Hospital, Medical School of Ningbo University, Ningbo 315010, China; more

Corresponding email(s):   nbluoqun@163.com

Key Words:  Liver-type fatty acid-binding protein, Neutrophil gelatinase-associated lipocalin, Kidney injury molecule-1, Percutaneous coronary intervention, Acute kidney injury

Hong-Hua Ye, Gen Shen, Qun Luo, Fang-Fang Zhou, Xiao-Ling Xie, Chun-Yan Wang, Li-Na Han. Early diagnosis of acute kidney injury in aged patients undergoing percutaneous coronary intervention[J]. Journal of Zhejiang University Science B, 2018, 19(5): 342-348.

@article{title="Early diagnosis of acute kidney injury in aged patients undergoing percutaneous coronary intervention",
author="Hong-Hua Ye, Gen Shen, Qun Luo, Fang-Fang Zhou, Xiao-Ling Xie, Chun-Yan Wang, Li-Na Han",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Early diagnosis of acute kidney injury in aged patients undergoing percutaneous coronary intervention
%A Hong-Hua Ye
%A Gen Shen
%A Qun Luo
%A Fang-Fang Zhou
%A Xiao-Ling Xie
%A Chun-Yan Wang
%A Li-Na Han
%J Journal of Zhejiang University SCIENCE B
%V 19
%N 5
%P 342-348
%@ 1673-1581
%D 2018
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1700427

T1 - Early diagnosis of acute kidney injury in aged patients undergoing percutaneous coronary intervention
A1 - Hong-Hua Ye
A1 - Gen Shen
A1 - Qun Luo
A1 - Fang-Fang Zhou
A1 - Xiao-Ling Xie
A1 - Chun-Yan Wang
A1 - Li-Na Han
J0 - Journal of Zhejiang University Science B
VL - 19
IS - 5
SP - 342
EP - 348
%@ 1673-1581
Y1 - 2018
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1700427

In aged patients, acute kidney injury (AKI) is a common clinical complication after percutaneous coronary intervention (PCI), highlighting the need for timely and certain diagnosis of this disease. A single centre, nested case-control study was conducted, which assessed the usefulness of urinary liver-type fatty acid-binding protein (uL-FABP), neutrophil gelatinase-associated lipocalin (uNGAL), and kidney injury molecule-1 (uKIM-1) for early detection of AKI. One hundred and thirty-two patients at or over 60 years old undergoing PCI were included. Serum creatinine (SCr) was measured before PCI, 24 and 48 h after PCI; uL-FABP, uNGAL, and uKIM-1 were measured before PCI, 6, 24, and 48 h after PCI. We identified 16 AKI patients and selected 32 control patients matched by admission time (<1 week), age (±5 years), and gender. In the receiver operating characteristic (ROC) curve analysis, the areas under the curve (AUCs) for the relative measurements of uL-FABP, uNGAL, and uKIM-1 were 0.809, 0.867, and 0.512 at 6 h after PCI, and 0.888, 0.840, and 0.676 at 24 h after PCI, respectively. AUC for the combination of uL-FABP and uNGAL was 0.899 at 6 h after PCI, and 0.917 at 24 h after PCI. Thus, measurement of uL-FABP and uNGAL levels at 6 and 24 h after PCI may be useful in detecting AKI in aged patients. Measurement of uKIM-1 levels provides inferior predictive power for early diagnosis of AKI.




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[23]Data S1 Materials, methods, and declarations

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