CLC number: R542.2
On-line Access: 2015-03-05
Received: 2014-08-31
Revision Accepted: 2015-01-08
Crosschecked: 2015-02-26
Cited: 2
Clicked: 5180
Xian-qing Hu, Jian Cheng, Biao Tang, Zhong-heng Zhang, Ke Huang, Yi-ping Yang, Yan-yan Mao, Ming Zhong, Shen-wen Fu. Clinical effect of postconditioning in ST-elevation myocardial infarction patients treated with primary percutaneous coronary intervention: a meta-analysis of randomized controlled trials[J]. Journal of Zhejiang University Science B, 2015, 16(3): 198-207.
@article{title="Clinical effect of postconditioning in ST-elevation myocardial infarction patients treated with primary percutaneous coronary intervention: a meta-analysis of randomized controlled trials",
author="Xian-qing Hu, Jian Cheng, Biao Tang, Zhong-heng Zhang, Ke Huang, Yi-ping Yang, Yan-yan Mao, Ming Zhong, Shen-wen Fu",
journal="Journal of Zhejiang University Science B",
volume="16",
number="3",
pages="198-207",
year="2015",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1400237"
}
%0 Journal Article
%T Clinical effect of postconditioning in ST-elevation myocardial infarction patients treated with primary percutaneous coronary intervention: a meta-analysis of randomized controlled trials
%A Xian-qing Hu
%A Jian Cheng
%A Biao Tang
%A Zhong-heng Zhang
%A Ke Huang
%A Yi-ping Yang
%A Yan-yan Mao
%A Ming Zhong
%A Shen-wen Fu
%J Journal of Zhejiang University SCIENCE B
%V 16
%N 3
%P 198-207
%@ 1673-1581
%D 2015
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1400237
TY - JOUR
T1 - Clinical effect of postconditioning in ST-elevation myocardial infarction patients treated with primary percutaneous coronary intervention: a meta-analysis of randomized controlled trials
A1 - Xian-qing Hu
A1 - Jian Cheng
A1 - Biao Tang
A1 - Zhong-heng Zhang
A1 - Ke Huang
A1 - Yi-ping Yang
A1 - Yan-yan Mao
A1 - Ming Zhong
A1 - Shen-wen Fu
J0 - Journal of Zhejiang University Science B
VL - 16
IS - 3
SP - 198
EP - 207
%@ 1673-1581
Y1 - 2015
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1400237
Abstract: Objective: To evaluate the clinical effect of postconditioning on patients with ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI). Methods: Randomized controlled trials were identified by searching relevant databases published up to April 2nd, 2014. A meta-analysis of eligible studies was performed by Stata 12.0 and Review Manager 5.2 with a fixed-effect model. Results: Ten studies providing adverse cardiac events in a total of 1346 STEMI patients treated with primary PCI were identified. The occurrence of heart failure was significantly reduced in patients treated with postconditioning compared with usual care (risk ratio (RR) 0.533; 95% confidence intervals (CI) 0.368–0.770), whereas non-fatal reinfarction slightly increased in the postconditioning group (RR 2.746; 95% CI 1.007–7.488). No significant difference in total major adverse cardiac events (MACEs) was observed between the two groups (RR 0.876; 95% CI 0.671–1.144). Conclusions: postconditioning in STEMI patients undergoing primary PCI significantly reduces the risk of heart failure, but fails to decrease the incidence of total MACEs and the risk of non-fatal reinfarction.
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