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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.5 P.369-377

http://doi.org/10.1631/jzus.B2000112


Comparison of epidemiological and clinical characteristics of COVID-19 patients with and without Wuhan exposure history in Zhejiang Province, China


Author(s):  Jiang-shan Lian, Huan Cai, Shao-rui Hao, Xi Jin, Xiao-li Zhang, Lin Zheng, Hong-yu Jia, Jian-hua Hu, Shan-yan Zhang, Guo-dong Yu, Jue-qing Gu, Chan-yuan Ye, Ci-liang Jin, Ying-feng Lu, Ji-fang Sheng, Yi-da Yang

Affiliation(s):  State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; more

Corresponding email(s):   yidayang65@zju.edu.cn

Key Words:  Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Zhejiang Province, Wuhan


Jiang-shan Lian, Huan Cai, Shao-rui Hao, Xi Jin, Xiao-li Zhang, Lin Zheng, Hong-yu Jia, Jian-hua Hu, Shan-yan Zhang, Guo-dong Yu, Jue-qing Gu, Chan-yuan Ye, Ci-liang Jin, Ying-feng Lu, Ji-fang Sheng, Yi-da Yang. Comparison of epidemiological and clinical characteristics of COVID-19 patients with and without Wuhan exposure history in Zhejiang Province, China[J]. Journal of Zhejiang University Science B, 2020, 21(5): 369-377.

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author="Jiang-shan Lian, Huan Cai, Shao-rui Hao, Xi Jin, Xiao-li Zhang, Lin Zheng, Hong-yu Jia, Jian-hua Hu, Shan-yan Zhang, Guo-dong Yu, Jue-qing Gu, Chan-yuan Ye, Ci-liang Jin, Ying-feng Lu, Ji-fang Sheng, Yi-da Yang",
journal="Journal of Zhejiang University Science B",
volume="21",
number="5",
pages="369-377",
year="2020",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2000112"
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%0 Journal Article
%T Comparison of epidemiological and clinical characteristics of COVID-19 patients with and without Wuhan exposure history in Zhejiang Province, China
%A Jiang-shan Lian
%A Huan Cai
%A Shao-rui Hao
%A Xi Jin
%A Xiao-li Zhang
%A Lin Zheng
%A Hong-yu Jia
%A Jian-hua Hu
%A Shan-yan Zhang
%A Guo-dong Yu
%A Jue-qing Gu
%A Chan-yuan Ye
%A Ci-liang Jin
%A Ying-feng Lu
%A Ji-fang Sheng
%A Yi-da Yang
%J Journal of Zhejiang University SCIENCE B
%V 21
%N 5
%P 369-377
%@ 1673-1581
%D 2020
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2000112

TY - JOUR
T1 - Comparison of epidemiological and clinical characteristics of COVID-19 patients with and without Wuhan exposure history in Zhejiang Province, China
A1 - Jiang-shan Lian
A1 - Huan Cai
A1 - Shao-rui Hao
A1 - Xi Jin
A1 - Xiao-li Zhang
A1 - Lin Zheng
A1 - Hong-yu Jia
A1 - Jian-hua Hu
A1 - Shan-yan Zhang
A1 - Guo-dong Yu
A1 - Jue-qing Gu
A1 - Chan-yuan Ye
A1 - Ci-liang Jin
A1 - Ying-feng Lu
A1 - Ji-fang Sheng
A1 - Yi-da Yang
J0 - Journal of Zhejiang University Science B
VL - 21
IS - 5
SP - 369
EP - 377
%@ 1673-1581
Y1 - 2020
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2000112


Abstract: 
Background: A novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first identified in wuhan, China, has been rapidly spreading around the world. This study investigates the epidemiological and clinical characteristics of coronavirus disease 2019 (COVID-19) patients in zhejiang Province who did or did not have a history of wuhan exposure. Methods: We collected data from medical records of confirmed COVID-19 patients in zhejiang Province from Jan. 17 to Feb. 7, 2020 and analyzed epidemiological, clinical, and treatment data of those with and without recorded recent exposure in wuhan. Results: Patients in the control group were older than those in the exposure group ((48.19±16.13) years vs. (43.47±13.12) years, P<0.001), and more were over 65 years old (15.95% control vs. 5.60% exposure, P<0.001). The rate of clustered onset was also significantly higher in the control group than in the exposure group (31.39% vs. 18.66%, P<0.001). The symptom of a sore throat in patients in the exposure group was significantly higher than that in the control group (17.30% vs. 10.89%, P=0.01); however, headache in the exposure group was significantly lower than that in the control group (6.87% vs. 12.15%, P=0.015). More patients in the exposure group had a significantly lower level of lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) than those in the control group. There was no significant difference in any degree of COVID-19 including mild, severe, and critical between the two groups. Conclusions: From the perspective of epidemiological and clinical characteristics, there was no significant difference between COVID-19 patients with and without wuhan exposure history.

浙江省有无武汉暴露史新型冠状肺炎患者的流行病学和临床特征的比较研究

目的:调查浙江省有武汉暴露史和无武汉暴露史的新型冠状肺炎患者的流行病学和临床特征.
创新点:探索新型冠状病毒从武汉市向浙江省传播过程中是否会发生流行病学和临床特征的变化.
方法:我们进行了一项回顾性研究.收集了2020年1月17日至2月7日浙江省确诊的新型冠状肺炎患者的流行病学和临床资料,并比较分析了有武汉暴露史和无武汉暴露史患者的流行病学和临床特征.
结论:从流行病学和临床特征的角度来看,有武汉暴露史和无武汉暴露史的新型冠状肺炎患者之间没有显著差异.

关键词:新型冠状病毒;SARS-CoV-2;浙江省;武汉

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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