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CLC number: R587.1

On-line Access: 2020-11-05

Received: 2020-04-30

Revision Accepted: 2020-08-05

Crosschecked: 2020-10-15

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Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Xia-hong Lin

https://orcid.org/0000-0002-5515-730X

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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.11 P.911-920

http://doi.org/10.1631/jzus.B2000225


Diagnostic value of optic disc retinal nerve fiber layer thickness for diabetic peripheral neuropathy


Author(s):  Xiao-hong Wu, Jing-wen Fang, Yin-qiong Huang, Xue-feng Bai, Yong Zhuang, Xiao-yu Chen, Xia-hong Lin

Affiliation(s):  Department of Endocrinology, the Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China; more

Corresponding email(s):   linxiahongdr@fjmu.edu.cn

Key Words:  Type 2 diabetes, Peripheral neuropathy, Retinal nerve fiber layer thickness, Optical coherence tomography, Diagnosis


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Xiao-hong Wu, Jing-wen Fang, Yin-qiong Huang, Xue-feng Bai, Yong Zhuang, Xiao-yu Chen, Xia-hong Lin. Diagnostic value of optic disc retinal nerve fiber layer thickness for diabetic peripheral neuropathy[J]. Journal of Zhejiang University Science B, 2020, 21(11): 911-920.

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journal="Journal of Zhejiang University Science B",
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pages="911-920",
year="2020",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2000225"
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Abstract: 
Objective: To investigate the value of optic disc retinal nerve fiber layer (RNFL) thickness in the diagnosis of diabetic peripheral neuropathy (DPN). Methods: Ninety patients with type 2 diabetes, including 60 patients without DPN (NDPN group) and 30 patients with DPN (DPN group), and 30 healthy participants (normal group) were enrolled. optical coherence tomography (OCT) was used to measure the four quadrants and the overall average RNFL thickness of the optic disc. The receiver operator characteristic curve was drawn and the area under the curve (AUC) was calculated to evaluate the diagnostic value of RNFL thickness in the optic disc area for DPN. Results: The RNFL thickness of the DPN group was thinner than those of the normal and NDPN groups in the overall average ((101.07± 12.40) µm vs. (111.07±6.99) µm and (109.25±6.90) µm), superior quadrant ((123.00±19.04) µm vs. (138.93±14.16) µm and (134.47±14.34) µm), and inferior quadrant ((129.37±17.50) µm vs. (143.60±12.22) µm and (144.48±14.10) µm), and the differences were statistically significant. The diagnostic efficiencies of the overall average, superior quadrant, and inferior quadrant RNFL thicknesses, and a combined index of superior and inferior quadrant RNFL thicknesses were similar, and the AUCs were 0.739 (95% confidence interval (CI) 0.635–0.826), 0.683 (95% CI 0.576–0.778), 0.755 (95% CI 0.652–0.840), and 0.773 (95% CI 0.672–0.854), respectively. The diagnostic sensitivity of RNFL thickness in the superior quadrant reached 93.33%. Conclusions: The thickness of the RNFL in the optic disc can be used as a diagnostic method for DPN.

视盘区视网膜神经纤维层厚度对糖尿病周围神经病变的诊断价值

目的:本文探讨视盘区视网膜神经纤维层(RNFL)厚度对糖尿病周围神经病变的诊断价值.
创新点:在进行糖尿病眼底检查的同时进行糖尿病周围神经病变的筛查,可以提高糖尿病周围神经病变的筛查效率.
方法:本文选择2型糖尿病患者无合并周围神经病变、2型糖尿病合并周围神经病变和健康对照组为研究对象,应用光学相干断层成像技术测定视盘区四个象限和整体平均RNFL厚度并进行比较,评估视盘区RNFL厚度对糖尿病周围神经病变的诊断价值.
结论:视盘区RNFL厚度可以作为糖尿病周围神经病变的一种诊断手段.

关键词:2型糖尿病;周围神经病变;视网膜神经纤维层厚度;光学相干断层成像技术;诊断

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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[40]Table S1 Complete nerve electromyography data of the DPN and NDPN groups

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