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Received: 2019-08-29

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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.4 P.305-314


Central visual function and inner retinal structure in primary open-angle glaucoma

Author(s):  Li-Juan Xu, Sha-Ling Li, Vance Zemon, Yan-Qian Xie, Yuan-Bo Liang

Affiliation(s):  Clinical and Epidemiological Eye Research Center, Eye Hospital, School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou 325027, China; more

Corresponding email(s):   yuanboliang@126.com

Key Words:  Isolated-check visual evoked potential (icVEP), Primary open-angle glaucoma (POAG), Optical coherence tomography (OCT), Standard automated perimetry (SAP)

Li-Juan Xu, Sha-Ling Li, Vance Zemon, Yan-Qian Xie, Yuan-Bo Liang. Central visual function and inner retinal structure in primary open-angle glaucoma[J]. Journal of Zhejiang University Science B, 2020, 21(4): 305-314.

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author="Li-Juan Xu, Sha-Ling Li, Vance Zemon, Yan-Qian Xie, Yuan-Bo Liang",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Central visual function and inner retinal structure in primary open-angle glaucoma
%A Li-Juan Xu
%A Sha-Ling Li
%A Vance Zemon
%A Yan-Qian Xie
%A Yuan-Bo Liang
%J Journal of Zhejiang University SCIENCE B
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1900506

T1 - Central visual function and inner retinal structure in primary open-angle glaucoma
A1 - Li-Juan Xu
A1 - Sha-Ling Li
A1 - Vance Zemon
A1 - Yan-Qian Xie
A1 - Yuan-Bo Liang
J0 - Journal of Zhejiang University Science B
VL - 21
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1900506

To investigate associations between central visual function and inner retinal structure in primary open-angle glaucoma (POAG). This study enrolled 78 POAG patients and 58 healthy controls. POAG was classified into early glaucoma and moderate to advanced glaucoma. The following tests were performed on all participants: isolated-check visual evoked potential (icVEP) testing, 24-2 standard automated perimetry (SAP), and Cirrus optical coherence tomography (OCT) examinations. Signal-to-noise ratio (SNR) measures obtained from icVEP responses to isolated checks presented at four depths of modulation (DOMs; 8%, 14%, 22%, and 32%) were explored. Mean macular sensitivity (mMS) was assessed by calculating the mean sensitivities of central 12 SAP points. Ganglion cell layer+ inner plexiform layer thickness (GCL+IPLT) and peripapillary retinal nerve fiber layer thickness (pRNFLT) were measured by OCT scanning. For each group of subjects, linear relationships among the following measures were analyzed: SNR, mMS, GCL+IPLT, and pRNFLT. SNR, mMS, GCL+IPLT, and pRNFLT were all more significantly decreased in glaucoma than in controls (P<0.001). A significant positive association was found between SNR at 14% DOM and GCL+IPLT at the inferior sector in early glaucoma (r=0.465, P=0.004). In moderate to advanced glaucoma, significant correlations were found between SNR at 32% DOM and mean GCL+IPLT (r=0.364, P=0.023), superior GCL+IPLT (r=0.358, P=0.025), and mean pRNFLT (r=0.396, P=0.025). In addition, in moderate to advanced glaucoma, there were significant correlations between mMS and all relevant measures of retinal thickness (r=0.330–0.663, P< 0.010). In early glaucoma, significant correlations were found between mean mMS and minimum GCL+IPLT (r=0.373, P=0.023), and between inferior mMS and superior GCL+IPLT (r=0.470, P=0.003). Linear models provided a good explanation for the relationship between SNR and inner retinal thickness (IRT), whereas nonlinear models better explained the relationship between mMS and IRT. In early glaucoma, both SNR and mMS were related moderately and significantly to IRT, whereas in moderate to advanced glaucoma, mMS was more strongly correlated with IRT than SNR.


创新点:POAG的潜在原因是视网膜神经节细胞(RGC)的丢失.虽然在传统上我们可以通过测量视网膜后极部约30°的结构和功能来评估青光眼性视神经损害,但是50%的RGC存在于黄斑区4.5 mm范围内.本研究关注黄斑区约10°范围视网膜结构和功能的关系,有助于更早地监测到青光眼性视神经损害.


Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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