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CLC number: R563.1

On-line Access: 2020-09-07

Received: 2020-05-16

Revision Accepted: 2020-07-05

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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.9 P.749-751

http://doi.org/10.1631/jzus.B2000253


Gastrointestinal involvement of COVID-19 and potential faecal transmission of SARS-CoV-2


Author(s):  Min Song, Zong-Lin Li, Ye-Jiang Zhou, Gang Tian, Ting Ye, Zhang-Rui Zeng, Jian Deng, Hong Wan, Qing Li, Jin-Bo Liu

Affiliation(s):  Department of Laboratory Medicine, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China; more

Corresponding email(s):   liujb7203@163.com

Key Words:  COVID-19, SARS-CoV-2, Gastrointestinal involvement, Faecal transmission


Min Song, Zong-Lin Li, Ye-Jiang Zhou, Gang Tian, Ting Ye, Zhang-Rui Zeng, Jian Deng, Hong Wan, Qing Li, Jin-Bo Liu. Gastrointestinal involvement of COVID-19 and potential faecal transmission of SARS-CoV-2[J]. Journal of Zhejiang University Science B, 2020, 21(9): 749-751.

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author="Min Song, Zong-Lin Li, Ye-Jiang Zhou, Gang Tian, Ting Ye, Zhang-Rui Zeng, Jian Deng, Hong Wan, Qing Li, Jin-Bo Liu",
journal="Journal of Zhejiang University Science B",
volume="21",
number="9",
pages="749-751",
year="2020",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2000253"
}

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%T Gastrointestinal involvement of COVID-19 and potential faecal transmission of SARS-CoV-2
%A Min Song
%A Zong-Lin Li
%A Ye-Jiang Zhou
%A Gang Tian
%A Ting Ye
%A Zhang-Rui Zeng
%A Jian Deng
%A Hong Wan
%A Qing Li
%A Jin-Bo Liu
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%@ 1673-1581
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2000253

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T1 - Gastrointestinal involvement of COVID-19 and potential faecal transmission of SARS-CoV-2
A1 - Min Song
A1 - Zong-Lin Li
A1 - Ye-Jiang Zhou
A1 - Gang Tian
A1 - Ting Ye
A1 - Zhang-Rui Zeng
A1 - Jian Deng
A1 - Hong Wan
A1 - Qing Li
A1 - Jin-Bo Liu
J0 - Journal of Zhejiang University Science B
VL - 21
IS - 9
SP - 749
EP - 751
%@ 1673-1581
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2000253


Abstract: 
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was found initially in Wuhan, China in early December 2019. The pandemic has spread to 216 countries and regions, infecting more than 23310 000 people and causing over 800 000 deaths globally by Aug. 24, 2020, according to World Health Organization (https://www.who.int/emergencies/diseases/ novel-coronavirus-2019). Fever, cough, and dyspnea are the three common symptoms of the condition, whereas the conventional transmission route for SARS-CoV-2 is through droplets entering the respiratory tract. To date, infection control measures for COVID-19 have been focusing on the involvement of the respiratory system. However, ignoring potential faecal transmission and the gastrointestinal involvement of SARS-CoV-2 may result in mistakes in attempts to control the pandemic.

COVID-19胃肠道感染和SARS-CoV-2潜在的粪便传播

概要:多中心临床数据显示,部分2019冠状病毒病(COVID-19)患者存在腹泻、恶心和呕吐等胃肠道症状,相关研究也证实严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)能够在胃肠道复制并从粪便中分离到活的SARS-CoV-2.在意大利和澳大利亚等国,其未处理的污水中检测到了SARS-CoV-2,且根据污水中SARS-CoV-2的含量估算出的COVID-19患者与临床实际感染患者较为一致.粪便中的SARS-CoV-2能够挥发存在于气溶胶中并保持较长时间的活力,故当人们暴露在被SARS-CoV-2污染的环境中即可能经"粪便-气溶胶-粘膜"途径感染SARS-CoV-2,而当人们食用被SARS-CoV-2污染的食物或水则可能经"粪-口"途径感染SARS-CoV-2.因此,对可能被COVID-19患者粪便污染的环境或物品进行严格管理和有效消毒对控制COVID-19大流行具有重要意义.
关键词:2019冠状病毒病(COVID-19);严重急性呼吸综合征冠状病毒2型(SARS-CoV-2);胃肠道感染;粪便传播

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]Ahmed W, Angel N, Edson J, et al., 2020. First confirmed detection of SARS-CoV-2 in untreated wastewater in Australia: a proof of concept for the wastewater surveillance of COVID-19 in the community. Sci Total Environ, 728:138764.

[2]Jin X, Lian JS, Hu JH, et al., 2020. Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms. Gut, 69(6):1002-1009.

[3]la Rosa G, Iaconelli M, Mancini P, et al., 2020. First detection of SARS-CoV-2 in untreated wastewaters in Italy. Sci Total Environ, 736:139652.

[4]Lamers MM, Beumer J, van der Vaart J, et al., 2020. SARS-CoV-2 productively infects human gut enterocytes. Science, 369(6499):50-54.

[5]Lee JJ, Kopetz S, Vilar E, et al., 2020. Relative abundance of SARS-CoV-2 entry genes in the enterocytes of the lower gastrointestinal tract. Genes (Basel), 11(6):645.

[6]Leung WK, To KF, Chan PKS, et al., 2003. Enteric involvement of severe acute respiratory syndrome-associated coronavirus infection. Gastroenterology, 125(4):1011-1017.

[7]Li W, Moore MJ, Vasilieva N, et al., 2003. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature, 426(6965):450-454.

[8]Liu Y, Ning Z, Chen Y, et al., 2020. Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals. Nature, 582(7813):557-560.

[9]Lu RJ, Zhao X, Li J, et al., 2020. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet, 395(10224):565-574.

[10]Nassar MS, Bakhrebah MA, Meo SA, et al., 2018. Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: epidemiology, pathogenesis and clinical characteristics. Eur Rev Med Pharmacol Sci, 22(15):4956-4961.

[11]https://doi.org/10.26355/eurrev_201808_15635

[12]Peiris JSM, Chu CM, Cheng VCC, et al., 2003. Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study. Lancet, 361(9371):1767-1772.

[13]Raj VS, Mou HH, Smits SL, et al., 2013. Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Nature, 495(7440):251-254.

[14]van Doremalen N, Bushmaker T, Morris DH, et al., 2020. Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1. N Engl J Med, 382(16):1564-1567.

[15]Wang WL, Xu YL, Gao RQ, et al., 2020. Detection of SARS-CoV-2 in different types of clinical specimens. JAMA, 323(18):1843-1844.

[16]Wu YJ, Guo C, Tang LT, et al., 2020. Prolonged presence of SARS-CoV-2 viral RNA in faecal samples. Lancet Gastroenterol Hepatol, 5(5):434-435.

[17]Xiao F, Tang MW, Zheng XB, et al., 2020. Evidence for gastrointestinal infection of SARS-CoV-2. Gastroenterology, 158(6):1831-1833.e3.

[18]Zhou J, Li C, Zhao GY, et al., 2017. Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus. Sci Adv, 3(11):eaao4966.

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