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On-line Access: 2021-09-10

Received: 2020-12-09

Revision Accepted: 2021-04-13

Crosschecked: 0000-00-00

Cited: 0

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Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Xin WEN

https://orcid.org/0000-0002-1649-3669

Hui QIU

https://orcid.org/0000-0002-5819-0965

Xin DING

https://orcid.org/0000-0001-6055-5292

Longzhen ZHANG

https://orcid.org/0000-0002-5786-1560

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Journal of Zhejiang University SCIENCE B 2021 Vol.22 No.9 P.774-781

http://doi.org/10.1631/jzus.B2000793


Pulsed low-dose rate radiotherapy has an improved therapeutic effect on abdominal and pelvic malignancies


Author(s):  Xin WEN, Hui QIU, Zhiying SHAO, Guihong LIU, Nianli LIU, Aoxing CHEN, Xingying ZHANG, Xin DING, Longzhen ZHANG

Affiliation(s):  Cancer Institute of Xuzhou Medical University, Xuzhou 221000, China; more

Corresponding email(s):   jsxyfyzlz@126.com, dingxin81@163.com

Key Words:  PLDR, HRS/IRR, Abdominal and pelvic cancers, T1/2


Xin WEN, Hui QIU, Zhiying SHAO, Guihong LIU, Nianli LIU, Aoxing CHEN, Xingying ZHANG, Xin DING, Longzhen ZHANG. Pulsed low-dose rate radiotherapy has an improved therapeutic effect on abdominal and pelvic malignancies[J]. Journal of Zhejiang University Science B, 2021, 22(9): 774-781.

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author="Xin WEN, Hui QIU, Zhiying SHAO, Guihong LIU, Nianli LIU, Aoxing CHEN, Xingying ZHANG, Xin DING, Longzhen ZHANG",
journal="Journal of Zhejiang University Science B",
volume="22",
number="9",
pages="774-781",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2000793"
}

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%A Xin WEN
%A Hui QIU
%A Zhiying SHAO
%A Guihong LIU
%A Nianli LIU
%A Aoxing CHEN
%A Xingying ZHANG
%A Xin DING
%A Longzhen ZHANG
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T1 - Pulsed low-dose rate radiotherapy has an improved therapeutic effect on abdominal and pelvic malignancies
A1 - Xin WEN
A1 - Hui QIU
A1 - Zhiying SHAO
A1 - Guihong LIU
A1 - Nianli LIU
A1 - Aoxing CHEN
A1 - Xingying ZHANG
A1 - Xin DING
A1 - Longzhen ZHANG
J0 - Journal of Zhejiang University Science B
VL - 22
IS - 9
SP - 774
EP - 781
%@ 1673-1581
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PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2000793


Abstract: 
Until now, there has been a lack of standard and effective treatments for patients with recurrent malignant tumors or abdominal and pelvic malignancies with extensive invasion (Morris, 2000). Generally, these patients face problems such as inability to undergo surgery or chemotherapy resistance (Combs et al., 2016). Re-radiotherapy has achieved a prominent place in the treatment of patients who have received radiotherapy previously and developed in-field recurrences (Straube et al., 2018). However, re-radiotherapy is very complicated, requiring comprehensive consideration of appropriate radiation dose, interval from first radiotherapy, boundary of the radiotherapy target area, and damage to surrounding normal tissues (Straube et al., 2019). In other words, it is necessary to focus on the protection of surrounding normal tissues while maximizing the efficacy of re-radiotherapy in such patients.

低剂量率脉冲放疗模式显著提高腹部盆腔恶性肿瘤的治疗效果

概要:低剂量率脉冲放射治疗(Pulsed low-dose rate,PLDR)是一种有效且安全的创新性放疗模式。这种放疗模式可用于肿瘤复发的再程放疗,同时肿瘤体积大、无法耐受常规放疗模式的肿瘤患者也能从中获得较好的姑息治疗疗效。在本研究中,我们首次提出了胰腺癌和前列腺癌的最佳PLDR模型,研究结果表明个性化的PLDR是一种有效的治疗腹部和盆腔癌的方法。

关键词:低剂量率脉冲放射治疗;低剂量辐射超敏感性/辐射抗性增强;腹盆腔恶性肿瘤;亚致死损伤半修复时间

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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