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CLC number: R62

On-line Access: 2018-11-02

Received: 2018-03-05

Revision Accepted: 2018-05-08

Crosschecked: 2018-10-10

Cited: 0

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Citations:  Bibtex RefMan EndNote GB/T7714


Ke-xin Song


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Journal of Zhejiang University SCIENCE B 2018 Vol.19 No.11 P.853-862


Hyperbaric oxygen therapy improves the effect of keloid surgery and radiotherapy by reducing the recurrence rate

Author(s):  Ke-xin Song, Shu Liu, Ming-zi Zhang, Wei-zhong Liang, Hao Liu, Xin-hang Dong, You-bin Wang, Xiao-jun Wang

Affiliation(s):  Department of Plastic Surgery, Peking Union Medical College Hospital, Beijing 100730, China; more

Corresponding email(s):   wybenz@sina.com, pumchwxj@163.com

Key Words:  Keloid, Hyperbaric oxygen therapy, Surgical excision, Radiotherapy, Recurrence rate

Ke-xin Song, Shu Liu, Ming-zi Zhang, Wei-zhong Liang, Hao Liu, Xin-hang Dong, You-bin Wang, Xiao-jun Wang. Hyperbaric oxygen therapy improves the effect of keloid surgery and radiotherapy by reducing the recurrence rate[J]. Journal of Zhejiang University Science B, 2018, 19(11): 853-862.

@article{title="Hyperbaric oxygen therapy improves the effect of keloid surgery and radiotherapy by reducing the recurrence rate",
author="Ke-xin Song, Shu Liu, Ming-zi Zhang, Wei-zhong Liang, Hao Liu, Xin-hang Dong, You-bin Wang, Xiao-jun Wang",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Hyperbaric oxygen therapy improves the effect of keloid surgery and radiotherapy by reducing the recurrence rate
%A Ke-xin Song
%A Shu Liu
%A Ming-zi Zhang
%A Wei-zhong Liang
%A Hao Liu
%A Xin-hang Dong
%A You-bin Wang
%A Xiao-jun Wang
%J Journal of Zhejiang University SCIENCE B
%V 19
%N 11
%P 853-862
%@ 1673-1581
%D 2018
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1800132

T1 - Hyperbaric oxygen therapy improves the effect of keloid surgery and radiotherapy by reducing the recurrence rate
A1 - Ke-xin Song
A1 - Shu Liu
A1 - Ming-zi Zhang
A1 - Wei-zhong Liang
A1 - Hao Liu
A1 - Xin-hang Dong
A1 - You-bin Wang
A1 - Xiao-jun Wang
J0 - Journal of Zhejiang University Science B
VL - 19
IS - 11
SP - 853
EP - 862
%@ 1673-1581
Y1 - 2018
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1800132

Objective: keloids are exuberant cutaneous scars that form due to abnormal growth of fibrous tissue following an injury. The primary aim of this study was to assess the efficacy and mechanism of hyperbaric oxygen therapy (HBOT) to reduce the keloid recurrence rate after surgical excision and radiotherapy. Methods: (1) A total of 240 patients were randomly divided into two groups. Patients in the HBOT group (O group) received HBOT after surgical excision and radiotherapy. Patients in the other group were treated with only surgical excision and radiotherapy (K group). (2) Scar tissue from recurrent patients was collected after a second operation. Hematoxylin and eosin (H&E) staining was used to observe keloid morphology. Certain inflammatory factors (interleukin-6 (IL-6), hypoxia-inducible factor-1α (HIF-1α), tumor necrosis factor-α (TNF-α), nuclear factor κB (NF-κB), and vascular endothelial growth factor (VEGF)) were measured using immunohistochemical staining. Results: (1) The recurrence rate of the O group (5.97%) was significantly lower than that of the K group (14.15%), P<0.05. Moreover, patients in the O group reported greater satisfaction than those in the K group (P<0.05). (2) Compared with the recurrent scar tissue of the K group, the expression levels of the inflammatory factors were lower in the recurrent scar tissue of the O group. Conclusions: Adjunctive HBOT effectively reduces the keloid recurrence rate after surgical excision and radiotherapy by improving the oxygen level of the tissue and alleviating the inflammatory process.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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