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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.2 P.102-122


Molecular hydrogen is a promising therapeutic agent for pulmonary disease

Author(s):  Zhiling FU, Jin ZHANG

Affiliation(s):  Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang 110004, China

Corresponding email(s):   zhangjin11170@163.com

Key Words:  Molecular hydrogen, Pulmonary disease, Reactive oxygen species (ROS), Oxidative stress, Inflammation

Zhiling FU, Jin ZHANG. Molecular hydrogen is a promising therapeutic agent for pulmonary disease[J]. Journal of Zhejiang University Science B, 2022, 23(2): 102-122.

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author="Zhiling FU, Jin ZHANG",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2100420

T1 - Molecular hydrogen is a promising therapeutic agent for pulmonary disease
A1 - Zhiling FU
A1 - Jin ZHANG
J0 - Journal of Zhejiang University Science B
VL - 23
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SP - 102
EP - 122
%@ 1673-1581
Y1 - 2022
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2100420

molecular hydrogen exerts biological effects on nearly all organs. It has anti-oxidative, anti-inflammatory, and anti-aging effects and contributes to the regulation of autophagy and cell death. As the primary organ for gas exchange, the lungs are constantly exposed to various harmful environmental irritants. Short- or long-term exposure to these harmful substances often results in lung injury, causing respiratory and lung diseases. Acute and chronic respiratory diseases have high rates of morbidity and mortality and have become a major public health concern worldwide. For example, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic. An increasing number of studies have revealed that hydrogen may protect the lungs from diverse diseases, including acute lung injury, chronic obstructive pulmonary disease, asthma, lung cancer, pulmonary arterial hypertension, and pulmonary fibrosis. In this review, we highlight the multiple functions of hydrogen and the mechanisms underlying its protective effects in various lung diseases, with a focus on its roles in disease pathogenesis and clinical significance.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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