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On-line Access: 2024-08-27

Received: 2023-10-17

Revision Accepted: 2024-05-08

Crosschecked: 2022-09-16

Cited: 0

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Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Jun YAO

https://orcid.org/0000-0002-2248-0370

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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.9 P.770-777

http://doi.org/10.1631/jzus.B2200156


Development and application of bionic systems consisting of tumor-cell membranes


Author(s):  Tianjiao PENG, Jun YAO

Affiliation(s):  Clinical Medical College, Henan University of Science and Technology, Luoyang 471003, China; more

Corresponding email(s):   yaojun74@163.com

Key Words:  Tumor cell membrane;Nanomedicine;Biomimetic nanoparticle, Drug delivery, Targeted therapy


Tianjiao PENG, Jun YAO. Development and application of bionic systems consisting of tumor-cell membranes[J]. Journal of Zhejiang University Science B, 2022, 23(9): 770-777.

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Abstract: 
Malignant tumors pose a serious threat to human health but during the past decade, great progress has been made in the treatment of tumors. The tumor-cell membrane is well constructed and can be used to solve problems in tumor therapy. Tumor-cell membranes exhibit not only high biocompatibility due to their homology but also enhanced therapeutic effects when combined with nanotechnology. Meanwhile, nanomaterials show high selectivity, sensitivity, and clinical transformation potential. Enhanced immunotherapy or tumor vaccines have potential clinical application because of tumor-membrane surface-specific antigens. Several studies have confirmed the feasibility and advantages of using tumor-cell membrane-incorporated nanosystems for tumor therapy. Considering all this, we focus in this review on the application of tumor-cell-membrane bionic platforms and, in the summary, provide ideas for new scientific developments.

一种潜在的技术--肿瘤细胞膜仿生系统

彭天娇1,2,3,姚俊2,3
1河南科技大学临床医学院,中国洛阳市,471003
2河南科技大学第一附属医院,肿瘤医院,中国洛阳市,471003
3河南科技大学第一附属医院,表观遗传学与分子生物学实验室,中国洛阳市,471003
摘要:恶性肿瘤严重威胁人类健康,近十年间,肿瘤治疗取得了突破性进展。肿瘤细胞膜仿生系统的发展进一步增强了肿瘤靶向策略。来源于自体的肿瘤细胞膜能够消除非生物因素,并显示出高度的生物相容性。此外,肿瘤的快速增殖和易于培养使肿瘤细胞膜比其他类型的生物膜更容易获得。本文首先介绍并回顾细胞膜仿生纳米系统的提出及发展,并且重点描述了在药物递送、光热和成像、肿瘤疫苗方面的应用。其次,对其安全性及可能存在的问题进行讨论。最后提出未来发展的可能方向。

关键词:肿瘤细胞膜仿生系统;恶性肿瘤;药物递送;光热治疗;肿瘤疫苗

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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