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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2300400


Wireless closed-loop deep brain stimulation using microelectrode array probes


Author(s):  Qianli JIA, Yaoyao LIU, Shiya LV, Yiding WANG, Peiyao JIAO, Wei XU, Zhaojie XU, Mixia WANG, Xinxia CAI

Affiliation(s):  State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100190, China; more

Corresponding email(s):   wangmixia@mail.ie.ac.cn, xxcai@mail.ie.ac.cn

Key Words:  Wireless closed-loop deep brain stimulation (CL-DBS) microsystem, Deep brain stimulation (DBS), Microelectrode array (MEA) probes, Optical stimulation, Electrical stimulation


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Qianli JIA, Yaoyao LIU, Shiya LV, Yiding WANG, Peiyao JIAO, Wei XU, Zhaojie XU, Mixia WANG, Xinxia CAI. Wireless closed-loop deep brain stimulation using microelectrode array probes[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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Abstract: 
deep brain stimulation (DBS), including optical and electrical stimulation, has demonstrated considerable value in exploring pathological brain activity and developing treatments for neural disorders. Advances in DBS microsystems based on implantable microelectrode array (MEA) probes have opened up new opportunities for closed-loop DBS (CL-DBS) in situ. This technology can be used to detect damaged brain circuits and test the therapeutic potential for modulating the output of these circuits in a variety of diseases simultaneously. Despite the success and rapid utilization of MEA probe-based CL-DBS microsystems, key challenges, including excessive wired communication, need to be urgently resolved. In this review we consider recent advances in MEA probe-based wireless CL-DBS microsystems and outline the major issues and promising prospects in this field. This technology has the potential to offer novel therapeutic options for psychiatric disorders in the future.

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