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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2300790


Olig2+ single-colony-derived cranial bone-marrow mesenchymal stem cells achieve improved regeneration in a cuprizone-induced demyelination mouse model


Author(s):  Deqing PENG, Ruijie LU, Leyao LV, Qing YAO, Kaichuang YANG, Yunfeng XU, Xiaoming FENG, Ruolang PAN, Yuyuan MA

Affiliation(s):  Center for Rehabilitation Medicine, Department of Neurosurgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang 310014, China.; more

Corresponding email(s):   18354233@qq.com, yuyuan_ma98246@163.com

Key Words:  Cranial bone marrow, single colony, mesenchymal stem cells, oligodendrocytes, demyelination


Deqing PENG, Ruijie LU, Leyao LV, Qing YAO, Kaichuang YANG, Yunfeng XU, Xiaoming FENG, Ruolang PAN, Yuyuan MA. Olig2+ single-colony-derived cranial bone-marrow mesenchymal stem cells achieve improved regeneration in a cuprizone-induced demyelination mouse model[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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%A Ruijie LU
%A Leyao LV
%A Qing YAO
%A Kaichuang YANG
%A Yunfeng XU
%A Xiaoming FENG
%A Ruolang PAN
%A Yuyuan MA
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A1 - Deqing PENG
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A1 - Qing YAO
A1 - Kaichuang YANG
A1 - Yunfeng XU
A1 - Xiaoming FENG
A1 - Ruolang PAN
A1 - Yuyuan MA
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PB - Zhejiang University Press & Springer
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Abstract: 
Multiple sclerosis (MS) is a major demyelinating disease of the central nervous system, with no effective treatment available at present. This study investigated the effects of cranial bone-marrow mesenchymal stem cells (cBMMSC) and Olig2+ single-colony-derived cBMMSC (sc-cBMMSC) in a central nervous system demyelination mouse model, which was established by cuprizone induction. cBMMSC and Olig2+ sc-cBMMSC were administered to the mice via tail vein at 1×106 cells/100µL PBS once a week for two weeks. One week after the completion of treatment, the mice in each group were evaluated for the relevant indicators. The results showed that cBMMSC transplantation could significantly improve the performance of CPZ-induced demyelinated mice in Rotarod, suspension, and water-maze tests. The levels of inflammatory factors, such as TNFα, IL-1β, and IL-6, in the peripheral and central nervous system of the mice were suppressed. Furthermore, the pathological structure was improved, with significantly restored myelin and increased expression of Olig2 and Syn. Of note, Olig2+ sc-cBMMSC achieved improved promotion of behavioral improvement, myelin repair, and nerve-cell regeneration in CPZ animals compared to cBMMSC. These findings suggest a reparative effect of cranial bone-marrow-derived stem cells in demyelination, which may be ascribed to the excellent immune regulation and protection of oligodendrocytes. The more pronounced effect of Olig2+ sc-cBMMSC transplantation further confirms the fact that heterogeneity of MSCs should be considered and utilized to improve the therapeutic effect in specific diseases.

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