CLC number:
On-line Access: 2024-12-30
Received: 2023-10-30
Revision Accepted: 2024-04-24
Crosschecked: 2024-12-30
Cited: 0
Clicked: 1272
Citations: Bibtex RefMan EndNote GB/T7714
Deqing PENG, Ruijie LU, Leyao L, Qing YAO, Kaichuang YANG, Yunfeng XU, Xiaoming FENG, Ruolang PAN, Yuyuan MA. Olig2+ single-colony-derived cranial bone-marrow mesenchymal stem cells achieve improved regeneration in a cuprizone-induced demyelination mouse model[J]. Journal of Zhejiang University Science B, 2024, 25(12): 1108-1114.
@article{title="Olig2+ single-colony-derived cranial bone-marrow mesenchymal stem cells achieve improved regeneration in a cuprizone-induced demyelination mouse model",
author="Deqing PENG, Ruijie LU, Leyao L, Qing YAO, Kaichuang YANG, Yunfeng XU, Xiaoming FENG, Ruolang PAN, Yuyuan MA",
journal="Journal of Zhejiang University Science B",
volume="25",
number="12",
pages="1108-1114",
year="2024",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2300790"
}
%0 Journal Article
%T Olig2+ single-colony-derived cranial bone-marrow mesenchymal stem cells achieve improved regeneration in a cuprizone-induced demyelination mouse model
%A Deqing PENG
%A Ruijie LU
%A Leyao L
%A Qing YAO
%A Kaichuang YANG
%A Yunfeng XU
%A Xiaoming FENG
%A Ruolang PAN
%A Yuyuan MA
%J Journal of Zhejiang University SCIENCE B
%V 25
%N 12
%P 1108-1114
%@ 1673-1581
%D 2024
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2300790
TY - JOUR
T1 - Olig2+ single-colony-derived cranial bone-marrow mesenchymal stem cells achieve improved regeneration in a cuprizone-induced demyelination mouse model
A1 - Deqing PENG
A1 - Ruijie LU
A1 - Leyao L
A1 - Qing YAO
A1 - Kaichuang YANG
A1 - Yunfeng XU
A1 - Xiaoming FENG
A1 - Ruolang PAN
A1 - Yuyuan MA
J0 - Journal of Zhejiang University Science B
VL - 25
IS - 12
SP - 1108
EP - 1114
%@ 1673-1581
Y1 - 2024
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2300790
Abstract: oligodendrocytes are the myelinating cells of the central nervous system. Brain injury and neurodegenerative disease often lead to oligodendrocyte death and subsequent demyelination-related pathological changes, resulting in neurological defects and cognitive impairment (Spaas et al., 2021; Zhang J et al., 2022). Multiple sclerosis (MS) is a major demyelinating disease of the central nervous system. The pathology of MS is characterized by the loss of myelin, oligodendrocytes, and axons in the brain, brain stem, and spinal cord, as well as by white matter lesions (Lassmann et al., 2007). Unfortunately, no definitive cure for MS has been developed. Immunomodulatory and anti-inflammatory drugs are effective in the relapsing-remitting phase of MS because they reduce the frequency of relapses and the formation of inflammatory lesions; however, they do not alter the course of progressive MS and are insufficient to cure chronic neurological dysfunction (Xiao et al., 2015; Zhang et al., 2021). The treatment outcome is even worse for MS patients with primary and secondary progressions. mesenchymal stem cells (MSCs) are stromal cells that can self-renew and exhibit multilineage differentiation. MSCs are easy to expand in vitro and exhibit low immunogenicity, no tumorigenic risks, and ethical controversies, making them a promising candidate for regenerative medicine (Zhang L et al., 2022; Xu et al., 2023). Many studies have confirmed the neural differentiation potential of MSCs under certain conditions, making them a prime candidate for treating neurodegenerative diseases (Jang et al., 2010; Yan et al., 2013). The present study investigated the effects of cranial bone-marrow mesenchymal stem cells (cBMMSCs) and oligodendrocyte-specific protein 2-positive (Olig2+) single-colony-derived cBMMSC (sc-cBMMSC), isolated in our previous work (Yang et al., 2022), in a central nervous system demyelination mouse model.
[1]AllegrettaC,D'AmicoE,ManutiV,et al.,2022.Mesenchymal stem cell-derived extracellular vesicles and their therapeutic use in central nervous system demyelinating disorders.Int J Mol Sci,23(7):3829.
[2]AvşarT,ErdemGÇ,TerzioğluG,et al.,2021.Investigation of neuro-inflammatory parameters in a cuprizone induced mouse model of multiple sclerosis.Turk J Biol,45(5):644-655.
[3]BiglariN,MehdizadehA,Vafaei MastanabadM,et al.,2023.Application of mesenchymal stem cells (MSCs) in neurodegenerative disorders: history, findings, and prospective challenges.Pathol Res Pract,247:154541.
[4]ConnerLT,SrinageshwarB,BakkeJL,et al.,2023.Advances in stem cell and other therapies for Huntington’s disease: an update.Brain Res Bull,199:110673.
[5]EldalyAS,MashalySM,FoudaE,et al.,2022.Systemic anti-inflammatory effects of mesenchymal stem cells in burn: a systematic review of animal studies.J Clin Transl Res,8(4):276-291.
[6]el SharounySH,ShaabanMH,ElsayedRM,et al.,2022.N-acetylcysteine protects against cuprizone-induced demyelination: histological and immunohistochemical study.Folia Morphol (Warsz),81(2):280-293.
[7]HedayatpourA,RagerdiI,PasbakhshP,et al.,2013.Promotion of remyelination by adipose mesenchymal stem cell transplantation in a cuprizone model of multiple sclerosis.Cell J,15(2):142-151.
[8]IslamMA,AlamSS,KunduS,et al.,2023.Mesenchymal stem cell therapy in multiple sclerosis: a systematic review and meta-analysis.J Clin Med,12(19):6311.
[9]JangS,ChoHH,ChoYB,et al.,2010.Functional neural differentiation of human adipose tissue-derived stem cells using bFGF and forskolin.BMC Cell Biol,11:25.
[10]KandeelM,MorsyMA,AlkhodairKM,et al.,2023.Mesenchymal stem cell-derived extracellular vesicles: an emerging diagnostic and therapeutic biomolecules for neurodegenerative disabilities.Biomolecules,13(8):1250.
[11]KashaniIR,HedayatpourA,PasbakhshP,et al.,2015.Progesterone enhanced remyelination in the mouse corpus callosum after cuprizone induced demyelination.Iran J Med Sci,40(6):507-514.
[12]KashaniSA,NavabiR,AminiA,et al.,2023.Immunomodulatory potential of human clonal mesenchymal stem cells and their extracellular vesicle subpopulations in an inflammatory-mediated diabetic rhesus monkey model.Life Sci,329:121950.
[13]LassmannH,BrückW,LucchinettiCF,2007.The immunopathology of multiple sclerosis: an overview.Brain Pathol,17(2):210-218.
[14]LyaminaS,BaranovskiiD,KozhevnikovaE,et al.,2023.Mesenchymal stromal cells as a driver of inflammaging.Int J Mol Sci,24(7):6372.
[15]MoQY,ZhangW,ZhuAJ,et al.,2022.Regulation of osteogenic differentiation by the pro-inflammatory cytokines IL-1β and TNF-α: current conclusions and controversies.Hum Cell,35(4):957-971.
[16]SoltiI,KvellK,TalaberG,et al.,2015.Thymic atrophy and apoptosis of CD4+CD8+ thymocytes in the cuprizone model of multiple sclerosis.PLoS ONE,10(6):e0129217.
[17]SpaasJ,van VeggelL,SchepersM,et al.,2021.Oxidative stress and impaired oligodendrocyte precursor cell differentiation in neurological disorders.Cell Mol Life Sci,78(10):4615-4637.
[18]VassallKA,BammVV,HarauzG,2015.Myelstones: the executive roles of myelin basic protein in myelin assembly and destabilization in multiple sclerosis.Biochem J,472(1):17-32.
[19]XiaoJ,YangRB,BiswasS,et al.,2015.Mesenchymal stem cells and induced pluripotent stem cells as therapies for multiple sclerosis.Int J Mol Sci,16(5):9283-9302.
[20]XuYZ,FanP,LiuL,et al.,2023.Novel perspective in transplantation therapy of mesenchymal stem cells: targeting the ferroptosis pathway.J Zhejiang Univ-Sci B (Biomed & Biotechnol),24(2):115-129.
[21]YanZJ,HuYQ,ZhangHT,et al.,2013.Comparison of the neural differentiation potential of human mesenchymal stem cells from amniotic fluid and adult bone marrow.Cell Mol Neurobiol,33(4):465-475.
[22]YangKC,LuRJ,LuJN,et al.,2022.Phenotypic and functional characterizations of mesenchymal stem/stromal cells isolated from human cranial bone marrow.Front Neurosci,16:909256.
[23]ZhangJ,BullerBA,ZhangZG,et al.,2022.Exosomes derived from bone marrow mesenchymal stromal cells promote remyelination and reduce neuroinflammation in the demyelinating central nervous system.Exp Neurol,347:113895.
[24]ZhangL,LiY,DongYC,et al.,2022.Transplantation of umbilical cord-derived mesenchymal stem cells promotes the recovery of thin endometrium in rats.Sci Rep,12:412.
[25]ZhangRB,LiuJ,XuB,et al.,2021.Cornuside alleviates experimental autoimmune encephalomyelitis by inhibiting Th17 cell infiltration into the central nervous system.J Zhejiang Univ-Sci B (Biomed & Biotechnol),22(5):421-430.
[26]ZhangYY,GuJB,WangXS,et al.,2023.Opportunities and challenges: mesenchymal stem cells in the treatment of multiple sclerosis.Int J Neurosci,133(9):1031-1044.
Open peer comments: Debate/Discuss/Question/Opinion
<1>