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On-line Access: 2024-08-27

Received: 2023-10-17

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Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Panke WANG

https://orcid.org/0000-0002-8733-9773

Anan LI

https://orcid.org/0000-0003-0037-5980

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Journal of Zhejiang University SCIENCE B 2024 Vol.25 No.10 P.824-840

http://doi.org/10.1631/jzus.B2400051


Odor representation and coding by the mitral/tufted cells in the olfactory bulb


Author(s):  Panke WANG, Shan LI, Anan LI

Affiliation(s):  School of Biomedical Engineering, Guangdong Medical University, Dongguan 523808, China; more

Corresponding email(s):   anan.li@xzhmu.edu.cn

Key Words:  Olfactory bulb, Mitral/tufted cells, Odor identity, Neural representation, Information encoding


Panke WANG, Shan LI, Anan LI. Odor representation and coding by the mitral/tufted cells in the olfactory bulb[J]. Journal of Zhejiang University Science B, 2024, 25(10): 824-840.

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DOI - 10.1631/jzus.B2400051


Abstract: 
The olfactory bulb (OB) is the first relay station in the olfactory system and functions as a crucial hub. It can represent odor information precisely and accurately in an ever-changing environment. As the only output neurons in the OB, mitral/tufted cells encode information such as odor identity and concentration. Recently, the neural strategies and mechanisms underlying odor representation and encoding in the OB have been investigated extensively. Here we review the main progress on this topic. We first review the neurons and circuits involved in odor representation, including the different cell types in the OB and the neural circuits within and beyond the OB. We will then discuss how two different coding strategies—spatial coding and temporal coding—work in the rodent OB. Finally, we discuss potential future directions for this research topic. Overall, this review provides a comprehensive description of our current understanding of how odor information is represented and encoded by mitral/tufted cells in the OB.

嗅球僧帽/簇状细胞对气味的表征和编码

王攀科1,李珊2,李安安2
1广东医科大学生物医学工程学院, 中国东莞市, 523808
2徐州医科大学江苏省脑病与生物信息学重点实验室, 生物化学与分子生物学研究中心, 中国徐州市, 221004
摘要:嗅球是嗅觉系统中的第一个中继站,起着关键的枢纽作用,能在不断变化的环境中精确地表征气味信息。作为嗅球中唯一的输出神经元,僧帽细胞/簇状细胞编码诸如气味类型和浓度等信息。近年来,针对嗅球中气味表征和编码的潜在神经策略和机制已开展了广泛的研究。本文对该领域的主要进展进行了综述,首先回顾了涉及气味表征的神经元和相关环路,包括嗅球中的不同细胞类型以及嗅球内部和外部的神经回路;随后讨论了两种不同的编码策略(空间编码和时间编码)在啮齿动物嗅球中的工作原理;最后,对该研究领域的潜在未来方向展开讨论。综上,本文就目前僧帽细胞/簇状细胞在嗅球中如何表征和编码气味信息进行了全面总结。

关键词:嗅球;僧帽/簇状细胞;气味类型;神经表征;信息编码

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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