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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2400341


Metapangenomics reveals an increased proportion of an Escherichia coli-dominated enterotype in older Chinese people


Author(s):  Jinyou LI, Yue WU, Yichen YANG, Lufang CHEN, Caihong HE, Shixian ZHOU, Shunmei HUANG, Xia ZHANG, Yuming WANG, Qifeng GUI, Haifeng LU, Qin ZHANG, and Yunmei YANG

Affiliation(s):  Key Laboratory of Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; more

Corresponding email(s):   1194070@zju.edu.cn, zhangqin1978@zju.edu.cn

Key Words:  Gut microbiome, Aging, Elderly population, Escherichia-dominated enterotype, Enterotype, Escherichia coli


Jinyou LI, Yue WU, Yichen YANG, Lufang CHEN, Caihong HE, Shixian ZHOU, Shunmei HUANG, Xia ZHANG, Yuming WANG, Qifeng GUI, Haifeng LU, Qin ZHANG, and Yunmei YANG. Metapangenomics reveals an increased proportion of an Escherichia coli-dominated enterotype in older Chinese people[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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A1 - Caihong HE
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A1 - Xia ZHANG
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A1 - Qifeng GUI
A1 - Haifeng LU
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Abstract: 
It is likely that gut microbial communities are remodeled in tandem with accumulated physiological decline during aging, yet there is limited understanding of gut microbiome variation in advanced age. Here, we performed a metagenomics-based enterotype analysis in a geographically homogeneous cohort of 367 enrolled Chinese individuals between the ages of 60 and 94, with the goal of characterizing the gut microbiome of the older individuals and identifying factors linked to enterotype variations. In addition to two adult-like enterotypes dominated by Bacteroides (ET-Bacteroides) and Prevotella (ET- Prevotella), we identified a novel enterotype dominated by Escherichia coli (ET- Escherichia), whose prevalence increased in advanced age. Our data demonstrated that age explained more of the variance in the gut microbiome than previously identified factors such as type 2 diabetes mellitus (T2DM) or diet. We characterized the distinct taxonomic and functional profile of ET- Escherichia, and found the strongest cohesion and highest robustness of the microbial co-occurrence network in this enterotype, as well as the lowest species diversity. In addition, we carried out a series of correlation analyses and co-abundance network analyses which showed that several factors were likely linked to the overabundance of Escherichia members, including advanced age, vegetable intake, and fruit intake. Overall, our data revealed an enterotype variation characterized by E. coli enrichment in the elderly population. Considering the different age distribution of each enterotype, these findings provide new insights into the changes that occur in the gut microbiome with age and highlight the importance of microbiome-based stratification of older individuals.

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